1431-Intratumoral Microbiota Remodeling and Immunotherapy
This review explores how intratumoral microbiota—the diverse collection of bacteria, fungi, and viruses living within tumors—shapes the immune microenvironment and impacts the success of cancer immunotherapy. While these microorganisms can boost treatment by activating T cells and signaling pathways like STING, they can also drive therapeutic resistance by fostering immunosuppressive conditions. The text highlights that microbial compositions are highly specific to tumor types, such as pancreatic or lung cancer, and are influenced by the tumor's microsatellite instability (MSI) status…
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