Latest / Wellness in Today's World / Ep. 26: Menopause, Midlife, and Women’s Well-Being
Transcript
- 0:05Welcome to Wellness in Today's World,
- 0:07the podcast where we discuss psychology,
- 0:10wellness, and everything in between.
- 0:12I'm your host, Debra Kawahara,
- 0:15and with each episode, we discuss how to live life better.
- 0:20Today we're exploring a topic that affects every woman who lives into midlife.
- 0:26Yet, for a long time, this topic has been either avoided,
- 0:31under-discussed,
- 0:33or simply just not focused on.
- 0:37Today, we're going to be looking at menopause and the broader experience
- 0:42of women during midlife. For many women,
- 0:45menopause is not just a biological transition.
- 0:50This stage of life actually affects many areas:
- 0:54physical health, emotional well-being,
- 0:57work,
- 0:59our relationships, our identity,
- 1:02and just quality of life. And yet this has been an area that
- 1:07has been kind of shunned, just not something that has been looked at.
- 1:13And today I am just so delighted that we have Dr.
- 1:18Rebecca Thurston here.
- 1:20a leading scientist, psychologist,
- 1:23and internationally known expert in women's health and menopause.
- 1:28Dr. Thurston is Associate Dean for Women's Health Research
- 1:33and Distinguished Professor of Psychiatry,
- 1:36Psychology, and Epidemiology at the University of Pittsburgh.
- 1:42I'm also so happy because Dr.
- 1:45Thurston served as a co-chair of My Presidential Task Force on Women's Health
- 1:52and Well-Being During Midlife and Menopause.
- 1:55And I'm just so thrilled to say that we have just recently released
- 2:01two groundbreaking reports: one on research
- 2:07in this area that also talks about the gaps and recommendations,
- 2:12and a second report that focuses on clinical care and recommendations
- 2:17for improving the health
- 2:19and well-being of women during this important stage of midlife and menopause.
- 2:24So Dr. Thurston, welcome to "Wellness in Today's World." I am just
- 2:29so pleased that you're here today.
- 2:31Thank you so much for having me.
- 2:32It's a privilege.
- 2:33Okay, let's get started because I have a whole bunch of questions that I want
- 2:38to ask and I want to be able to tap into your expertise.
- 2:42You know, when I was first talking about doing a presidential initiative
- 2:49on this area, many women came up to me and just felt relieved that someone
- 2:55was saying that this was real.
- 2:58I just wanted to ask you, why has it taken so
- 3:01long for us to recognize this as something important since women
- 3:06are half the population? And you know,
- 3:10women have been going through this for millennia.
- 3:12So what do you think?
- 3:13Mm-hmm. Yeah. Yeah.
- 3:16Yeah, it's kind of striking, right?
- 3:17This sort of natural life transition that just about all of us,
- 3:21~ those who are born female, will experience.
- 3:24And it's a kind of extended duration,
- 3:26depending on how you measure it,
- 3:28accompanied by a lot of different health changes and symptoms,
- 3:31et cetera, et cetera. So it's really interesting.
- 3:33I think it
- 3:34reflects kind of the general shame that we've had around menopause,
- 3:38~ because it's kind of this confluence of reproductive health,
- 3:42~ gynecologic health, and aging and women's health.
- 3:46And I think we've kept this in the shadows for so long.
- 3:49And I really think it's wonderful that it's coming out of the shadows,
- 3:52that people are talking about it,
- 3:54that women are really demanding answers.
- 3:56And ~ it's losing that kind of
- 3:59flavor of secrecy and shame. So I think it's great,
- 4:03but it reflects our cultural attitudes towards women's health,
- 4:06aging, and anything kind of touching the space of gynecology.
- 4:11Yeah.
- 4:12And you know, when you have talked about it,
- 4:14'cause I've seen you present, I've seen your work,
- 4:18you talk about it as it is really important to not only think about this
- 4:23as a biological stage or biological transition.
- 4:28You kind of talk about it from a biopsychosocial framework.
- 4:32Mm-hmm.
- 4:32And really to be careful not to just talk about,
- 4:35"Oh, this is a hormonal change that,
- 4:38you know, women go through." What does that biopsychosocial framework mean
- 4:44and why is that an important distinction?
- 4:47Yeah, I mean, I think what we've learned over the years,
- 4:49particularly with our longitudinal cohort studies where we follow women over
- 4:52the course of the menopause transition and see what changes,
- 4:56and also in my clinical work, how do we address this clinically?
- 5:00It's become clear that this is a major multi-system transition and it's impacting
- 5:05on multiple aspects of physical health,
- 5:08~ whether it's cardiovascular health,
- 5:10brain health, bone health, ~ muscle health,
- 5:13etc.
- 5:14Mental health, of course. And the underlying drivers of all of those changes
- 5:20are not only hormones. I think we've learned that the hormones matter,
- 5:23but there's other things like sleep,
- 5:26vasomotor symptoms, etc. While we're having menopause
- 5:31in this reproductive transition or multi-system transition,
- 5:35we're also having midlife aging.
- 5:36And that's where some of those role transitions come into play,
- 5:39midlife psychological development,
- 5:41perspectives on your future and your past,
- 5:44that kind of reflection. So all those things are happening at the same time,
- 5:47which I think makes it a really interesting and ~ beautiful time of life
- 5:52to both study, to be in, and to treat clinically.
- 5:56And one of the things that I know you talk about a lot and as I,
- 6:02over time, have kind of followed you,
- 6:04you really do focus on kind of the more comprehensive impact
- 6:10Mm-hmm.
- 6:11that midlife, you know, and menopause have on women.
- 6:15And I wanted you to talk a
- 6:17more about the relationship between menopause and perimenopause and health
- 6:23Mm-hmm.
- 6:23and well-being.
- 6:24Yeah, yeah. And maybe I should start with defining some terms,
- 6:28like what is the menopause, right?
- 6:28Okay, Yeah!
- 6:31So, you know, and how we stage it.
- 6:34Between menarche and the perimenopause is called the premenopause,
- 6:37and that's when we have our regular reproductive cycling.
- 6:40Theoretically, ~ we have fecundity or the ability to have children during that time.
- 6:46And then your menstrual cycles become kind of irregular,
- 6:48usually in the 40s for most women,
- 6:50whether it's early 40s, mid-40s,
- 6:52and that's when you're starting to enter into this early perimenopausal period.
- 6:56~ And then when you start skipping menstrual cycles,
- 6:59once you skip two menstrual cycles,
- 7:01you've gone 60 days without a period,
- 7:02you are entering into the late perimenopause.
- 7:05And after 12 months of no menstrual cycles,
- 7:08you are in the postmenopause, and that's where you stay the rest of your life.
- 7:11And really, where a lot of the action that we see is during
- 7:16the perimenopausal period. And this can go on for quite a long time,
- 7:19between the early and the late perimenopause.
- 7:21On average, it's about four years,
- 7:22but it can extend much longer for some women.
- 7:25And then the early, those first couple years of the postmenopause,
- 7:29we see a lot of changes. This is both you see dramatic changes
- 7:33in reproductive hormones. So your hormones may be bouncing around from
- 7:37one month to the next during the perimenopause.
- 7:40And then they kind of, especially estrogen,
- 7:43estradiol from the ovary, that will like decline very dramatically right around that
- 7:48final menstrual period, onset of postmenopause.
- 7:50But you also, 70 to 80 percent of women are having hot flashes,
- 7:53about half of women are having sleep problems,
- 7:56about half of women are having cognitive symptoms like brain fog.
- 8:00And then you're also seeing accelerations in underlying atherosclerosis,
- 8:04which is one of our drivers of cardiovascular disease.
- 8:08We're seeing pretty rapid declines in bone density right around that final menstrual
- 8:12period. And then we're investigating in one of our studies,
- 8:14we don't know this for sure yet,
- 8:15but we think you're probably gonna see also some changes in the brain when
- 8:19you image women serially
- 8:20Mmm.
- 8:20over the course of the menopause transition.
- 8:22Although those data used in neuroimaging are much more slim,
- 8:25and that's why we have this big MetaBrain study to do that.
- 8:28So there's a lot of different changes happening all at the same time.
- 8:31And then when it comes to mental health,
- 8:32you're seeing increases in depressive symptoms and major depressive disorder,
- 8:36particularly for women who've had symptoms in the past.
- 8:39And then we can get into all the other mental health diagnoses and how much
- 8:43we don't know actually, but also
- 8:44Mm-hmm.
- 8:45there's some data for increases in anxiety as well.
- 8:47~ So you're seeing all these changes on the mental health side,
- 8:50physical health side, and hormones,
- 8:53sleep, cognitive symptoms, also general urinary symptoms.
- 8:57So you're also seeing many women starting to have vaginal dryness,
- 9:01pain with penetration,
- 9:02Hmm.
- 9:03irritation of your genital tissues that also oftentimes accompany
- 9:08the menopause transition, whether it's during the peri or postmenopause,
- 9:11or sometimes for some women it comes on really later in the postmenopausal period.
- 9:15There's some variability around that.
- 9:16So that's also a common change we see.
- 9:19Okay, that was a whole lot of information!
- 9:22Yeah. Yeah.
- 9:23~
- 9:24But one of the things that I took is that you're really talking about this being
- 9:29a lifespan process, that it's
- 9:31Mm-hmm.
- 9:32not only this small stage. So you had talked about menarche
- 9:36to kind of perimenopause,
- 9:39Yeah.
- 9:39you know, and I guess one of the things that I have thought about,
- 9:43and just to organize my thoughts is
- 9:46in that stage, you know, because oftentimes I think people aren't thinking about
- 9:51menopause when you're in your 30s or 40s,
- 9:54and yet you're already saying in your 40s,
- 9:57you may already start experiencing symptoms.
- 10:00So
- 10:00Absolutely.
- 10:01At that stage, are there any indicators or protective factors
- 10:07in terms
- 10:07Mm-hmm.
- 10:07of then going into menopause that those women could do?
- 10:12Yeah, I mean one of the things that we know is that the earlier menopause
- 10:17is associated with a number of adverse health outcomes.
- 10:21So particularly a premature menopause.
- 10:23Now, premature menopause or premature ovarian insufficiency happens when
- 10:26you go through menopause before age 40.
- 10:28And we know that those women are at increased cardiovascular disease risk,
- 10:32~ fracture risk for bone health,
- 10:34neurocognitive risk, or they have their ovaries taken out very young,
- 10:39before 40 or before they reach menopause.
- 10:42So those women are definitely a group at risk.
- 10:45And maybe there's some data that sort of having postmenopause on the earlier side
- 10:50is not so great either. Now is there anything you can do to extend that
- 10:53and push that back? Is that kind of the question,
- 10:55is can you modify that timing?
- 10:57I mean the the most kind of consistent risk factors for an earlier menopause
- 11:02is smoking. Smoking is very toxic to the ovaries.
- 11:05So ~ if you're a smoker, to quit smoking.
- 11:09And beyond that, we know that oral contraceptives,
- 11:12at least the higher dose oral contraceptives sometimes delay menopause,
- 11:16but we're talking about plus or minus a year.
- 11:18So ~ modifying that timing,
- 11:21there's not a lot of modifiable risk factors as far as we're aware besides smoking.
- 11:25That's unfortunately where we're at with that.
- 11:28Now, in order to forestall some of the health changes associated,
- 11:32the adverse health changes, such as the cardiovascular changes,
- 11:35~ that's an active area of inquiry.
- 11:38But we do know doing all of those positive cardiovascular ~ behaviors,
- 11:44such as managing blood pressure,
- 11:46treating diabetes, staying physically active,
- 11:49trying to maintain weight at within
- 11:51what we consider a healthy range,
- 11:53~ eating things like a Mediterranean diet.
- 11:56Those are all the things you want to do for your heart health that
- 11:58are going to apply at any time of life,
- 12:00and menopause as well. We do not know at this point whether taking hormone therapy
- 12:06will forestall those changes, except when it comes to bone.
- 12:10So for cardiovascular and brain,
- 12:12and this is probably a longer conversation around hormone therapy,
- 12:15the jury's still out and we can get into that.
- 12:18But you can forestall the bone changes with hormone therapy at an adequate dose.
- 12:24So you have to take enough ~ estradiol,
- 12:26but as soon as you go off the hormones,
- 12:29you will lose the bone density.
- 12:31So that's something to keep in mind.
- 12:33You know, as you were talking,
- 12:35I was thinking about, okay, from there,
- 12:38then moving into menopause. And I know you've done the SWAN study,
- 12:43which has studied women across their lifespan.
- 12:47And so I actually wanted you to talk about some of the research that you've done,
- 12:53some of the findings that you've done that would be informative.
- 12:57One of the things I've heard is women feel really underprepared
- 13:02for this stage of life.
- 13:02Yeah.
- 13:03Yeah. I will talk about some of the research we've done and then what would
- 13:07I say to women, right? So what can you do?
- 13:08Okay, excellent. Yeah.
- 13:09How do you prepare yourself, right?
- 13:11So some of the key findings have been,
- 13:14for example, those vasomotor symptoms,
- 13:16those hot flashes that so many of us get,
- 13:18whether it's hot flashes or night sweats collectively are known
- 13:21as vasomotor symptoms, that
- 13:22persistent severe vasomotor symptoms are associated with a 70% increased risk
- 13:27of heart attacks, strokes, and cardiovascular disease mortality over
- 13:31the subsequent 20 years. Also,
- 13:33persistent sleep problems, so trouble falling asleep,
- 13:36waking a lot during the night,
- 13:37waking up earlier than you wanted,
- 13:39you know, like five in the morning kind of thing;
- 13:41not due to your schedule, but rather insomnia,
- 13:44persistent insomnia symptoms are also associated with a similar magnitude
- 13:49of risk from a cardiovascular perspective and a doubling of risk of stroke.
- 13:52And also we see that those vasomotor symptoms are associated with poor
- 13:56neurocognitive health later in life as well.
- 13:58So greater circulating amyloid,
- 14:01~ as well as what we call white matter hyperintensities in the brain.
- 14:04So these are markers of cerebral small vessel damage in the brain.
- 14:07So risk factors for stroke, essentially,
- 14:09and dementia. So those hot flashes and night sweats are things,
- 14:14and the sleep problems, to not just kind of suffer through.
- 14:17These are symptoms that are both bothersome and disruptive to your daily life.
- 14:22And when they start interfering with your daily life,
- 14:25I would say get treatment for them.
- 14:26Mm.
- 14:27And don't necessarily let them go on and on,
- 14:28particularly when it comes to the sleep problems.
- 14:31We have a pretty good body of research from other times of life that similarly
- 14:36reflect that persistent insomnia is something that has a widespread impact
- 14:40on the body and the brain, and that treating those sleep problems can be helpful.
- 14:45Now we lack data specific to the menopause transition,
- 14:47whether treating them can impact heart and brain health.
- 14:49And we don't yet know whether treating the vasomotor symptoms improves heart
- 14:53and brain health.
- 14:54But I also am of the mantra like,
- 14:56"Suffering is overrated." So if you're suffering with these symptoms,
- 14:58Okay. ~
- 15:00~ get treatment. Okay, so
- 15:02what would I say to women?
- 15:05I would say, first of all, suffering is overrated.
- 15:07Don't just try to gut this out if it's really disruptive.
- 15:10Also, for some people, menopause is no big deal.
- 15:12Like they're fine.
- 15:13Mm-hmm.
- 15:14They don't have severe symptoms.
- 15:15And in that case, it's fine. You know,
- 15:17you don't necessarily need to get treated.
- 15:19But if you are suffering, let's find you a good menopause-trained provider.
- 15:23Also, that the symptoms may start earlier than you think.
- 15:27So don't be surprised if you start having hot flashes or brain fog
- 15:33or mood changes in your early 40s,
- 15:35or for some even their late 30s,
- 15:37we see some
- 15:38Yeah.
- 15:38hot flashes; starts earlier than we think and it lasts longer
- 15:42than we think, particularly when it comes to the vasomotor symptoms.
- 15:45Those can last on average about seven to ten years.
- 15:47Also, women of color, particularly black women,
- 15:51will experience their vasomotor symptoms earlier,
- 15:53more severely, and for much longer,
- 15:55for reasons that we don't fully understand.
- 15:57So I think there's a lot of variability in these symptom trajectories,
- 16:02but they can be quite bothersome for some women.
- 16:04And one of the earliest symptoms to emerge are those neurocognitive symptoms.
- 16:09The brain fog, the forgetting why you walk into the room.
- 16:12Many women think that they are dementing and losing their minds
- 16:17or developing early onset dementia.
- 16:19It's very rarely the case that that is what's happening.
- 16:22Oftentimes it's this perimenopausal brain fog that we're still trying
- 16:26to get our hands around, but we do not think it necessarily portends
- 16:30~ a dementing process.
- 16:32As you brought up the different symptoms that women may be experiencing
- 16:38and not to ignore them or dismiss them,
- 16:40but to actually get them assessed and treated if there is treatment
- 16:46for them. What if you go to a provider and they're kind of not taking it seriously,
- 16:52for lack of a better
- 16:53Yeah.
- 16:54way of saying it? What should someone do in that case?
- 16:57Yeah,
- 16:58Yeah, for sure. And not to pathologize all the symptoms.
- 17:01If the symptoms are mild and they're not bothering you,
- 17:03fine, don't worry about it. But again,
- 17:04if it's really bothersome and disrupting your life,
- 17:06that's when you really want to,
- 17:08you know, make sure you're getting them treated.
- 17:08Mm-hmm.
- 17:09~ Now,
- 17:10how to find
- 17:10Yeah.
- 17:11a good menopause provider. Now this is...
- 17:12Now we completely have acknowledged that a big problem in the field is
- 17:17the lack of really well-trained menopause providers across subspecialties.
- 17:22And menopause knowledge
- 17:25doesn't exist or belong solely to gynecology.
- 17:28That's kind of where it lives right now.
- 17:29But in my personal opinion is it really needs to ~ transcend discipline
- 17:35and medical subspecialty, behavioral health subspecialty.
- 17:39And really we all need a little bit of training,
- 17:40at least a little bit in menopause,
- 17:42because, you know, again, this is a universal transition.
- 17:45So what do you do? Right now, the best-trained people are typically gynecologists.
- 17:49So talk to your gynecologist first.
- 17:51Now, if your gynecologist isn't responsive,
- 17:53isn't listening to you, or doesn't seem to know about menopause,
- 17:56you know, you can talk to your PCP,
- 17:58you may encounter the same issue.
- 18:00So where I send people is The Menopause Society,
- 18:03a nonprofit medical scientific organization.
- 18:06They maintain a directory of providers who have gained certification
- 18:10in menopause knowledge and care.
- 18:12And that is a great place to go to find a good
- 18:15menopause-trained provider ~ based upon evidence-based care.
- 18:19One of the other big problems we're having in the menopause space
- 18:23is people realizing that there's a real gap ~ in terms
- 18:26Mm.
- 18:26of the care that women are receiving and trying to meet this with non-evidence-based
- 18:31care. And there's a lot of profiteering,
- 18:32unfortunately, going on in the space.
- 18:33No.
- 18:34So buyer beware when it comes to these internet providers or just everybody
- 18:38you see on Instagram or... Not to say that they're all bad.
- 18:41It's hard to know as the layperson which is evidence-based,
- 18:45which is not, which is why I send people to The Menopause Society website.
- 18:48So being very careful about where you're getting your information.
- 18:53Hopefully it's accurate and evidence-based.
- 18:53Mm-hmm. Mm-hmm.
- 18:56And The Menopause Society, which I know you're a past president,
- 19:00is one place where you can go and get accurate resources and connect with providers
- 19:07that are trained in this area.
- 19:07Yep.
- 19:08Excellent. I mean, I think that a lot of women are trying to figure out,
- 19:12"How do I navigate this?"
- 19:15Because even your providers may not be trained in knowing what to do.
- 19:19But one of the things that you
- 19:21did in the report, and I was very pleased with,
- 19:24is you talked about the positive impacts,
- 19:27because we generally focus on the symptomatology and the treatment.
- 19:30Yeah.
- 19:31But you actually talked about the positive impact at this stage in women's lives.
- 19:37So, talk about that.
- 19:37Yeah.
- 19:39You know, I think that there is all this gloom and doom around menopause.
- 19:43And I honestly think that it's good to validate people's concerns,
- 19:46but we also don't want to scare people,
- 19:48particularly people who are coming into it and say that this is this horrible time
- 19:51of life. Because, really, midlife aging,
- 19:53you know, and this is where we have both menopause and midlife aging
- 19:57as a developmental transition happening at the same time.
- 19:59Even just menopause alone, I think particularly when the periods stop
- 20:03and some of the symptoms abate,
- 20:04there is a lot of relief and women really do report feeling quite freed.
- 20:08So even menopause itself can be a freeing experience.
- 20:11But also midlife aging; rarely do I speak to a midlife woman who wants
- 20:16to go backwards and wishes she actually were in her twenties or thirties,
- 20:19because you oftentimes gain a substantial amount of wisdom,
- 20:24self-awareness;
- 20:26you care a little bit less about what people think about you,
- 20:28and that's incredibly freeing.
- 20:30~
- 20:31Mm-hmm.
- 20:31And we have this kind of dialogue,
- 20:33"Oh, midlife women become invisible,
- 20:35and isn't that so sad?" For some people,
- 20:38having a little bit- not being the object of so much either sexual harassment
- 20:43or cat-calling, that kind of thing can be great.
- 20:46When you're less the object of scrutiny,
- 20:50you have a lot more freedom too.
- 20:52So in general, women aging into midlife find it to be a time
- 20:57of increased groundedness, empowerment,
- 21:00and self-awareness,
- 21:02and self-acceptance.
- 21:03And that's why I kind of conceptualize
- 21:06us treating the negative parts of menopause,
- 21:08but really elevating that sort of personal psychological growth
- 21:13and championing it and helping,
- 21:15as mental health providers,
- 21:16to further that and ~ support that I think is really important.
- 21:21I guess I think about the strength-based approach in this period of life,
- 21:28that it's almost as though you come into your own,
- 21:32and
- 21:32Mm-hmm.
- 21:33really having that confidence and agency to
- 21:37Mm-hmm.
- 21:38now move forward in your life.
- 21:40You know, one of the things that I did want
- 21:42you to talk about a bit, because I know we also did clinical care
- 21:47and potential treatments that are out there for women that
- 21:52may be experiencing symptomatology from menopause.
- 21:57So I wanted you to talk a little bit about that and some of the things that could
- 22:02be considered in terms of treatment.
- 22:05Yeah.
- 22:05Yeah.
- 22:06And what we really should do is pair the treatment with the symptom that we're
- 22:10talking about. ~
- 22:11Okay.
- 22:11And there's no one magic bullet.
- 22:13We so want one magic bullet, whether it's anti-aging
- 22:16Mm-hmm.
- 22:17or treating all the menopausal symptoms at once.
- 22:19~ And we have fallen into this trap a couple of times when it comes
- 22:22to hormone therapy over history,
- 22:24but really we need to tailor the treatment to the symptoms.
- 22:28So for example, for vasomotor symptoms,
- 22:30the most effective treatment
- 22:32is hormone therapy. Actually, one of the only FDA-approved indications
- 22:36for hormone therapy is the treatment of vasomotor symptoms.
- 22:38So hot flashes, night sweats. Now,
- 22:40other treatments for vasomotor symptoms,
- 22:42we have a whole class, a new class of agents called neurokinin 3
- 22:46or neurokinin 1-3 receptor antagonists that have been FDA-approved that
- 22:50are very effective in treating hot flashes non-hormonally.
- 22:54So fezolinetant and elinzanetant are two of those drugs.
- 22:58And those are something that you can take and there's increasing body
- 23:02of literature around those. People will also use SSRIs and SNRIs
- 23:07to help manage their vasomotor symptoms,
- 23:09particularly if there is also a mood component involved with their menopause
- 23:14experience. And other people use gabapentin in an off-label fashion,
- 23:18especially if there's also a sort of sleep component.
- 23:21Okay, so that's the vasomotor symptoms.
- 23:24Yeah.
- 23:24Now, sleep.
- 23:25The most effective treatment for sleep insomnia at any time of life,
- 23:30menopause included, is CBTI, Cognitive Behavioral Therapy for Insomnia.
- 23:35So if your sleep problems are not exclusively secondary to your nighttime
- 23:40hot flashes, then CBTI is really the way to go.
- 23:43So oftentimes I'll like get people's hot flashes treated and then treat their sleep
- 23:48through CBTI. I'll assess whether they have any evidence
- 23:51of sleep-disordered breathing;
- 23:53make sure they're getting a workup for that.
- 23:54That's something like sleep apnea,
- 23:56which also can increase during the menopause transition,
- 23:58which we want to treat that through standard methods such as CPAP,
- 24:01etc. So we want to understand what's driving the sleep problems.
- 24:04Yeah.
- 24:04And then CBTI is typically the way to go.
- 24:06Genitourinary syndrome of menopause,
- 24:08~ vaginal estrogen is the way to go with this.
- 24:11So these are typically creams or tablets or rings that
- 24:15are specifically acting locally at the genital tissues.
- 24:20And that is really kind of our gold standard treatment.
- 24:23And these are very low dose, they're not typically systemically absorbed,
- 24:28so it doesn't necessarily raise your blood levels very much.
- 24:30It's really acting at those local tissues.
- 24:32So it's safe for even people who typically don't want to take hormone therapy
- 24:37systemically. Cognitive symptoms,
- 24:39we don't necessarily know what to do yet.
- 24:41We're in the process
- 24:41Interesting.
- 24:42of developing, trying to understand what's driving them.
- 24:46But what I do clinically is I first treat the sleep,
- 24:50because the sleep can sometimes be driving the cognitive symptoms,
- 24:53and treat any psychiatric symptoms,
- 24:55mood and anxiety, because that's,
- 24:57you know, cognitive symptoms are a feature of depression as well.
- 25:01So I try to treat these other things that might be driving the cognitive symptoms.
- 25:04So those are the most common symptoms that I see.
- 25:05Yep. Yeah.
- 25:07And I usually do a different path for each one.
- 25:09Really helpful. I mean, I think just to know that it's not gonna be,
- 25:14"Just take estrogen and you'll be-
- 25:16it'll all go away," ~ which
- 25:18Yeah.
- 25:19I think ~ oftentimes that's what's thought.
- 25:21But there's
- 25:22Yeah.
- 25:22so much more. It's, you know, our bodies are complicated.
- 25:26Yeah.
- 25:26And there's a lot of variability in both the patterns of symptoms that people will
- 25:32~ follow over time. We've characterized this from the SWAN studies.
- 25:36So for example, some women
- 25:36Uh-huh.
- 25:37have their hot flashes when they're pre or perimenopausal,
- 25:39some people have them largely after their periods have stopped,
- 25:41some people have the entire time.
- 25:43So even just that one symptom,
- 25:45there's also a
- 25:46really profound variability. Now with the cognitive symptoms,
- 25:49some people anecdotally report benefit from hormone therapy,
- 25:53but it really is going to depend on what's driving those cognitive symptoms,
- 25:56Mm-hmm.
- 25:57which is why I really try to do a pretty good workup to understand what some
- 26:01of those other drivers would be.
- 26:03But yeah, there's no magic bullet as much as we wish there were.
- 26:06I know.
- 26:06~ But sadly, sadly,
- 26:10the world doesn't work that way.
- 26:11Yeah.
- 26:11Well, and in general, treatment doesn't work that way,
- 26:14right? Everybody's so different and there's a diversity of how our bodies respond
- 26:21to certain things. I think what you were kind of presenting is that depending upon
- 26:28what is going on exactly, that the practitioner needs to really get
- 26:32to what exactly the source of the
- 26:35Mm-hmm.
- 26:35symptoms and you may need to be treating
- 26:38the symptom to then figure out,
- 26:40okay, how is this interrelated or not related to what I'm seeing
- 26:44for this other symptom?
- 26:46And it's also very dynamic. So...
- 26:48Yeah.
- 26:48The symptom presentation in the early perimenopause may look really different than
- 26:53those two years postmenopausal.
- 26:55That's par for the course. Like these things
- 26:56Yeah.
- 26:56are changing over time. So also yourself and your own body,
- 27:00if things start to feel different or things are,
- 27:02all of a sudden you have a different symptom,
- 27:04it's hard because you feel really out of control,
- 27:07like what's happening with my body?
- 27:07Yeah.
- 27:08But it also is common and just keep
- 27:12in touch with your providers as your symptom constellations change over
- 27:16the course of this very dynamic transition.
- 27:19And as the provider, we need to kind of continue to reassess and check
- 27:23in and make sure that we understand the status at that point in time.
- 27:27I'm so glad that you said that.
- 27:29'Cause oftentimes, you know, you hear women saying,
- 27:32"I'm going crazy. I don't know what's happening with me." And it's really gonna
- 27:37be important that you have a good relationship with your provider that understands
- 27:42this may change as you're going through it.
- 27:45You may be reporting different things that are going on,
- 27:48and you're not crazy. I guess that's the thing that I really want to hit home.
- 27:52Yeah, you're not crazy. It's not all in your head,
- 27:55so to speak.
- 27:56Yeah.
- 27:56You're not imagining things. These things do originate largely
- 28:00in the central nervous system.
- 28:01So there's that piece. It is in the level of the hypothalamus where a
- 28:04lot the hot flashes are originating,
- 28:06but it is not in your imagination.
- 28:08And you deserve to have your experience validated and somebody to really listen
- 28:13to you and take your concerns seriously.
- 28:15And that's where that
- 28:16patient-provider relationship is really important and making sure that you're seeing
- 28:21somebody who you feel like listens to you and validates you.
- 28:25And as I say that, I know that's really easier said than done.
- 28:28But yet we also know that that quality of the relationship between
- 28:32the patient and the provider is one of the strongest predictors
- 28:34of positive outcomes across a range of different health conditions.
- 28:37So, you know, keep at it. Don't give up.
- 28:39Yeah. I mean, I think that part of the dialogue right now
- 28:44is really important because you started our episode talking about the shame
- 28:49and kind of
- 28:49Mm-hmm.
- 28:49the silence around menopause. As we talk about it more,
- 28:53hopefully it does validate women like,
- 28:56you're experiencing something real and to actually take what they're experiencing
- 29:02seriously and not dismiss it.
- 29:04Absolutely.
- 29:05So I wanted to talk about kind of on the larger societal level,
- 29:09because oftentimes I've also heard stories about,
- 29:13how do I deal with work when these symptoms aren't exactly ~ acknowledged,
- 29:19you know, like brain fog or, you know,
- 29:22I'm not sleeping well or my mood is...
- 29:25Let's talk about kind of the larger impact
- 29:28on the societal level because I know you've talked about the losses just even
- 29:32economically, the workforce, etc.,
- 29:34Mm, yeah, yeah.
- 29:36and why this
- 29:37is important for employers to understand.
- 29:41Yeah. I mean, this is pretty massive on a societal level because also when you're
- 29:45hitting your forties and fifties,
- 29:47for many women, this is when you're at the top of your game professionally,
- 29:50depending on what your career is.
- 29:53You know, and there's always a fine line when talking about menopause
- 29:57in the workplace, because the last thing I want to do is stigmatize women,
- 30:01or at least I definitely don't want to give
- 30:05uUs any more ammunition against aging women in the workforce,
- 30:08Yes.
- 30:09right? Because there also is so much discrimination as it is,
- 30:12which is why I think in many times there was so much silence about this,
- 30:15and women were just sort of trying to gut through.
- 30:19But there are some really wonderful resources from the Society
- 30:22for Women's Health Research that has a whole compendium of resources for employers.
- 30:26And in the UK, there's actually quite a lot of work going on on the workplace level
- 30:32about how to better support this very important aspect of their workforce,
- 30:39right? Like there's a huge amount of knowledge and skill and productivity that
- 30:45can be gained by supporting women,
- 30:48midlife women, transition through this time from the workplace perspective.
- 30:52There's been some economic modeling of the profound cost
- 30:56that menopause and untreated menopausal symptoms are,
- 31:00both on a societal level and also on a workforce and workplace level.
- 31:04So the estimates range, but they're just big numbers,
- 31:07let's just say that, depending on what you include in that.
- 31:10Whether it's lost days, whether it's partial days,
- 31:13whether it's leaving the workforce,
- 31:15whether it's declining a promotion,
- 31:18whether it's healthcare expenses,
- 31:19all these things really add up to the billions.
- 31:22What do we wanna do about that?
- 31:24There are resources available,
- 31:26and I think this is an area where there's also a lot of active development,
- 31:30but employers can really have adaptations depending on the type
- 31:36of work you're doing. If it's very hot,
- 31:38if you're wearing a lot of heavy clothes,
- 31:40if you need to take breaks, if you need to rethink the temperature
- 31:44in the environment. I would say
- 31:46good health insurance is a pretty basic thing that employers
- 31:49Yeah.
- 31:49can do. Make sure that things like reproductive health care,
- 31:52particularly menopausal care, is covered.
- 31:55And awareness, education,
- 31:58dialogue, and listening to their employees around what the midlife women really need
- 32:03in that particular work setting,
- 32:05because it really needs to be tailored to the work setting.
- 32:07So employers really should have this on their radar screen as something that,
- 32:11if you want
- 32:14to have the most productivity from your employees,
- 32:16be sure you're addressing the midlife and menopause-related needs of your workforce.
- 32:21Okay. I think that's a charge ~ that you're giving,
- 32:25Yeah. Yeah. Yes.
- 32:27right?
- 32:28Because many women, like you said,
- 32:30many women work and this is when kind of they're at the height of their career
- 32:35and really making strides. And so you want them to continue to be able
- 32:40Right. Right.
- 32:41to work optimally. ~
- 32:43When you're sleeping four hours a night,
- 32:45it's very hard to work optimally.
- 32:48Or if you're struggling with depressive or anxious symptoms,
- 32:50it's very hard. In fact some of the estimates,
- 32:52particularly the Mayo Clinic estimates,
- 32:54one of the strongest predictors of workplace cost were the mental health symptoms
- 32:59associated with menopause.
- 32:59Hmm.
- 33:00We can't dismiss those; that's part of the picture.
- 33:03And I think rather than use this as a cudgel to discriminate against women or
- 33:08Yeah.
- 33:08prevent them from promoting them,
- 33:10I think employers really need to be thinking about how to support and meet
- 33:15the needs of the midlife women in the workplace.
- 33:18I'm gonna give you a magic wand.
- 33:20Yeah.
- 33:21And if you could, you know, at the societal level,
- 33:24I'm thinking of federal regulations or policies because you wrote about research
- 33:30gaps and recommendations and,
- 33:32Yes.
- 33:32you know, clinical care and what we could be doing to improve women's health
- 33:37and well being.
- 33:39And so I'm giving you a magic wand.
- 33:41What would you wish would happen in order for women to be able to be supported,
- 33:48to live their best lives?
- 33:49Yeah. And I think that this has to happen at multiple levels of society.
- 33:54And I do not claim to be a policy expert,
- 33:56but I'll tell you just
- 33:56Yeah, yeah.
- 33:57from what I would like to see,
- 33:59and it's quite systemic. First of all,
- 34:02how do we continue to- and I think we're doing this and just continue
- 34:06the momentum of destigmatizing menopause,
- 34:09destigmatizing midlife aging for women,
- 34:12I think is crucial. I think we kind of really need to continue
- 34:15to support women's rights and well-being and their reproductive rights across
- 34:22the full lifespan, not only during the reproductive years,
- 34:26but during the post-reproductive years.
- 34:28Some of this is really about women's stature in society.
- 34:32So that's just
- 34:34kind of a backdrop. When we start
- 34:35Yeah.
- 34:35to erode women's rights across the board,
- 34:37whether it's the right to vote,
- 34:39whether it's rights to access comprehensive health care,
- 34:41we're eroding their rights across the board and it'll make everything worse.
- 34:45So that's that's sort of the backdrop.
- 34:46Mm-hmm.
- 34:47Now, menopause-specific things,
- 34:49there's so many things. ~ In thinking through a medical lens,
- 34:53we have to make menopause treatments accessible and affordable.
- 34:57And this is not only hormone therapy,
- 34:59this is a full range of menopause care.
- 35:01Although we do need to fix the problems we're having with the patches,
- 35:05and we do need to train our providers in menopause care,
- 35:09which I'm gonna come to in a second.
- 35:10But the full range of menopause care,
- 35:12accessible, affordable, for all.
- 35:14We do need to also ~ train our providers in menopause care.
- 35:20And this is not only OB/GYNs, which I think is crucial,
- 35:24it's internal medicine, family practice,
- 35:26psychologists, social workers,
- 35:29neurologists, cardiologists, rheumatologists,
- 35:32across the board. So each subspecialty should learn the thing that's relevant
- 35:36to their subspecialty, just some basics.
- 35:38So they don't need a deep, comprehensive menopause education like you might
- 35:41do with the OB/GYNs or the internal medicine,
- 35:43but they do need to understand how this relates,
- 35:46given that they're gonna be seeing menopausal women.
- 35:48And I don't know how one goes about this,
- 35:50because I think this is a problem across multiple realms,
- 35:53is the problem of misinformation and profiteering
- 35:55Mm-hmm.
- 35:56with non-evidence-based care. This is a problem.
- 35:59Do I know how we should address this as a society?
- 36:02No, but we start at least with education and awareness.
- 36:08And it would be wonderful to have some sort of comprehensive education for
- 36:14women and their partners, the men in their life as well.
- 36:17So kind of like we do with pregnancy or kind of like we do with menarche,
- 36:21you get like a little training module before you go into that.
- 36:24Why not? Why aren't we doing this with menopause as well?
- 36:28I think it's also the backdrop of how much do we value women and how much
- 36:31do we value aging women in our society?
- 36:33Absolutely. I mean, as you were saying that,
- 36:35it's like, yeah, fifth grade. You learn about the menstrual cycle.
- 36:40Why not add on the rest of the lifespan transition kind of events?
- 36:46I really appreciate that. As we're closing up,
- 36:50you know, we started with, you know,
- 36:53talking about women feeling unprepared,
- 36:56feeling as though they can't talk about menopause.
- 36:59So I wanted to end our
- 37:02conversation with two or three key takeaways from today's episode,
- 37:07what would you want that to be?
- 37:09Trust yourself, trust your experience.
- 37:12It's like, everybody goes through this in their own way and their
- 37:16own constellation of symptoms.
- 37:17And if your symptom doesn't look like your friend's symptoms
- 37:20or your mother's symptoms, that's fine.
- 37:21~ You are having your experience,
- 37:23and your experience may change over time.
- 37:25Advocate for yourself, get the care that you need,
- 37:28beware of non-evidence-based care and treatments that you're seeing online.
- 37:33Remember, it's not all bad. That this is actually an incredible time of life.
- 37:39And while you can feel really out of control,
- 37:43things are changing and they're not always changing for the bad.
- 37:47Continue to look for those ways in which you feel like this is
- 37:51an opportunity to either make changes in your life or to embrace a part
- 37:55of yourself that you haven't been able to before.
- 37:58Lean into it.
- 37:59It's a wonderful time of life and when you come out the other side of it,
- 38:03you're gonna feel great.
- 38:04Powerful. Powerful. You know, Dr.
- 38:07Thurston, thank you so much for being here today and sharing your wisdom,
- 38:12your insight, and your passion for advancing women's health and well-being,
- 38:17particularly during midlife and and menopause.
- 38:22I think one of the things that I take away is that this is a very complex
- 38:27and complicated period of time for women,
- 38:30but
- 38:32that there can be positives to it.
- 38:34Trust yourself in knowing what your body's telling you,
- 38:37to get good information
- 38:40and to work closely with your provider
- 38:42Absolutely.
- 38:43Thank you so much for being here.
- 38:45I just feel like this conversation is just scratching the surface,
- 38:49but it's
- 38:49Is this?
- 38:50one of the small steps that we need to make in order for women to feel empowered
- 38:56to take action when they are maybe suffering.
- 38:59I also believe you don't get a medal at the end of your life for
- 39:03the amount of suffering that you're doing.
- 39:06So, get it addressed. Hopefully you feel better and that you can live your life
- 39:11thriving. So thank you again. And to the listeners,
- 39:12Absolutely.
- 39:15I hope that you can take some of this information that we talked about today
- 39:19and continue to learn, address anything that you're going through,
- 39:25and share it with others as well.
- 39:28As we end, as always, remember that wellness is a journey,
- 39:33not a destination. And I hope that you will take care of yourself and others.
- 39:38So until the next time, please take good care.