Dr. Neil Iyengar, Dr. Joyce O'Shaughnessy, & Dr. Ana Garrido-Castro - Evolving ADCs in 1L mTNBC

Community Health Media · Jun 26, 2026 · 38m

The first-line treatment landscape for metastatic triple-negative breast cancer is changing rapidly.

Dr. Neil Iyengar, Dr. Joyce O'Shaughnessy, and Dr. Ana Garrido-Castro discuss how ADCs are reshaping frontline TNBC care and what the latest clinical evidence means for real-world practice.

The conversation explores:

The evolution of metastatic TNBC treatment

Why many patients never reach second-line therapy

The impact of ASCENT and sacituzumab govitecan

ASCENT-03 and ASCENT-04 trial results

TROPION-Breast02 and datopotamab deruxtecan

The role of crossover in interpreting overall survival

PFS…