1498-Intrinsic Cardiac Nervous System in Heart Function
The research article identifies the intrinsic cardiac nervous system (ICNS) as a vital regulatory hub, rather than a simple relay, that is essential for heart function and survival. By using advanced genetic and imaging techniques, the researchers discovered two distinct neuronal subtypes, Npy+ and Ddah1+, which possess unique anatomical and physiological roles. Npy+ neurons are responsible for parasympathetic heart rate control and maintaining baseline performance; their loss leads to catastrophic cardiac failure. In contrast, Ddah1+ neurons act as a protective mechanism during stressful…
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