237-A novel human heart-macrophage assembloid (hHMA)

Paper Talk · Nov 17, 2025 · 22m

This article introduces a novel human heart-macrophage assembloid (hHMA) platform, which integrates pluripotent stem cell-derived embryonic monocytes into heart organoids to mimic natural immune-cardiac interactions during development. The researchers demonstrate that these tissue-resident macrophages (TRMPs) successfully integrate, persist long-term, and regulate vital cardiac functions, including morphogenesis, efferocytosis, and electrical conduction. Furthermore, the hHMAs provide a powerful in vitro model for disease by demonstrating that chronic activation of the NLRP3 inflammasome in…