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E103: Does HOP Actually Work? Real Data From a 5-Year Study (Quickisode)

Does a Human & Organizational Performance (HOP) initiative improve learning and the quality of actions? And what happens when the initiative stops?This quickisode unpacks Christopher Mastrangelo’s 2026 Master’s thesis examining a multi-year HOP implementation at a large biopharmaceutical company. His project tracked operational data from 2020 through July 2025 across key metrics: a. deviation initiation ratesb. root cause classification practicesc. CAPA types, andd. cultural persistence after formal support was removed. The HOP initiative seemingly resulted in:a. A drop in quality…

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