1499-Cellular Phenotypes of Language in ALS
This scientific study explores the cellular and molecular foundations of cognitive decline in individuals with amyotrophic lateral sclerosis (ALS) by mapping the prefrontal cortex. Using advanced multimodal spatial profiling and single-nucleus sequencing, researchers identified that different cognitive impairments arise from unique biological processes rather than a single disease mechanism. Specifically, language and fluency deficits were linked to widespread inflammatory responses in the glia and blood vessels across the brain. In contrast, executive dysfunction was associated with…
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