667-A Pan-Cancer Resource of 1,294 Plasma cfDNA Methylomes
This research presents a comprehensive pan-cancer resource consisting of 1,294 plasma cell-free DNA samples to improve noninvasive tumor detection. By developing a standardized computational workflow, the authors integrated DNA methylation and fragmentomic data across eleven distinct cancer types. The study identified thousands of cancer-associated markers while effectively mitigating technical biases and biological confounders like age and sex. Their findings demonstrate that combining methylation with fragmentation features—such as 5′ end motifs and fragment ratios—significantly enhances…
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