935-Muscle EVs and miR-126 Regulate TDP-43 and NMJ Integrity

Paper Talk · May 8, 2026 · 24m

This research explores how a specific communication pathway between muscles and nerves contributes to the development of Amyotrophic Lateral Sclerosis (ALS). The study identifies that the protein TDP-43 builds up abnormally in the distal parts of motor neurons because of a failure in local protein regulation. Scientists discovered that muscles normally send out microRNA-126 through tiny vesicles to prevent this harmful protein accumulation at the neuromuscular junction. When this signaling process is disrupted, the resulting protein buildup inhibits essential cellular functions, leading to…