400-A clinical road map for single-cell omics

Paper Talk · Jan 15, 2026 · 14m

While single-cell omics has revolutionized biological research, this perspective outlines the experimental, computational, and conceptual hurdles preventing its routine use in clinical medicine. The authors argue for a transition from simple discovery to the development of actionable biomarkers that integrate data across multiple cell types to improve precision diagnosis and personalized therapy. Current obstacles include the high cost of scaling patient cohorts, the prevalence of statistically flawed analysis workflows, and the need for standardized protocols that meet regulatory…