824-SPTEdU-seq: Spatiotemporal Newborn Cell Tracking
The paper introduce SPTEdU-seq, a sophisticated spatial omics platform that simultaneously tracks newborn cell dynamics and maps the spatial total transcriptome. This innovative method utilizes optics-free detection via single-molecule probes and click chemistry, allowing researchers to study delicate cellular states without the damage caused by traditional imaging. By capturing both coding and non-coding RNAs as well as splicing isoforms, the technology provides a more comprehensive molecular view than previous techniques. The researchers demonstrated its utility by reconstructing…
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