Latest / MIT - Conversations with MIT Health / Piecing Together Perimenopause | Interview with Dr. Adi Ratner Nevo
Transcript
- 0:02Emily Wade (Host): A while back, we asked our listeners here at Office
- 0:05Hours to send us that health question that you've been googling at 2:00 AM.
- 0:10It's no surprise our MIT night owls sent us back some very specific
- 0:14replies, but among them was this extremely relatable question.
- 0:20"Dear Office Hours, if I'm googling at 2:00 AM, I'm asking
- 0:24about perimenopause symptoms.
- 0:26Am I on enough estrogen?
- 0:28Is my hair shed normal, or is it problematic?
- 0:32And how on earth did my mother survive her 40s and 50s?
- 0:35You know, normal stuff."
- 0:38So, on today's episode, we have Dr.
- 0:41Adi Rattner Nevo from MIT Health Primary Care to help us unravel the
- 0:47mysteries of the internet's current favorite women's health topic.
- 0:52Welcome, Adi.
- 0:54Adi Rattner Nevo, MD: Thanks so much, Emily.
- 0:55So happy to be here.
- 0:57Host: I'm so happy that you are here because you had a
- 1:03presentation at our town hall recently where you actually specifically
- 1:07talked about how people are asking a lot of perimenopause questions.
- 1:11So, this is very exciting to have you here to talk about this hot topic.
- 1:18And definitely while I am not, you know, up at 2:00 AM googling perimenopause,
- 1:24at some point, my Instagram algorithm definitely decided I'm in hormonal peril.
- 1:30So, you know, I'm going to get a lot out of this too.
- 1:34The question we have today is really interesting because there's two
- 1:38things about it that are really important, where it's like, you
- 1:42know, how did my mother survive her 40s and 50s is a very relatable and
- 1:48emotionally accurate medical question.
- 1:50But also, I think, a really key thing about this question is how are you
- 1:57supposed to find kind of like trustworthy and reliable information when the
- 2:02internet is, like, eager to give you 700 answers to every question, and many of
- 2:09those answers are advertising a product or service or patch or cream that's
- 2:15supposed to solve all of your problems?
- 2:17So, to get started there, let's just get to the basics.
- 2:23What is perimenopause?
- 2:26Adi Rattner Nevo, MD: Thanks, Emily.
- 2:26These questions are very relevant.
- 2:28So, perimenopause is the transition leading up to menopause.
- 2:33During this time, the ovaries start producing hormones less consistently,
- 2:37especially estrogen and progesterone, and the fluctuations in hormone
- 2:42levels could be pretty significant.
- 2:44This can lead to a range of symptoms.
- 2:46Menopause is officially defined as 12 months without having a menstrual
- 2:51period, but perimenopause is the transition before that point that can
- 2:55last for several years for some people.
- 2:59Host: So, it's kind of less of a moment, like a specific moment
- 3:03in time, and more of a phase.
- 3:05So, it's kind of funny that peri- is doing a lot in perimenopause.
- 3:10It's like it's shruggie pause really.
- 3:15Adi Rattner Nevo, MD: Exactly.
- 3:16It is a gradual transition, usually not an overnight change.
- 3:20Host: That's true.
- 3:21But I feel like sometimes emotionally, it can feel like you could go have
- 3:27a, you know, normal life and then, all of a sudden, you wake up in the
- 3:30middle of the night and you're like, "My mattress is like Death Valley,
- 3:35and I'm like covered in sweat.
- 3:37And what's happening to me?"
- 3:40So, it's like it does seem like there are pieces that can
- 3:44kind of come out of nowhere.
- 3:47Is that normal?
- 3:48Is that the case?
- 3:50Adi Rattner Nevo, MD: So, that can be the experience of many people.
- 3:53You know, and the thing that I talk about with patients is that people, your
- 3:57friends can experience it very differently from you, but there are some common
- 4:02symptoms that this can include starting to see changes in menstrual cycle, hot
- 4:07flashes, night sweats you're referring to.
- 4:09Otherwise, trouble sleeping, mood changes, brain fog, vaginal dryness,
- 4:15changes in libido or sex drive, headaches, joint aches, changes in
- 4:19hair or skin, and there are more.
- 4:23But the most important thing to remember is that sometimes these
- 4:26symptoms can represent other processes or medical conditions, but
- 4:31they can happen in perimenopause.
- 4:34Host: But if you're in, you know, your 40s, and these symptoms are
- 4:38starting to come along, s it a good guess to assume it's perimenopause?
- 4:45Adi Rattner Nevo, MD: It's a reasonable possibility, but not
- 4:47always the answer that these symptoms are solely from perimenopause.
- 4:51So, a lot of these symptoms, you know, can come from the hormonal
- 4:54changes, but also can show up in other conditions like thyroid disorder,
- 4:59anemia, depression, sleep apnea, side effects of medications that people may
- 5:04be on, pregnancy, and chronic stress.
- 5:09So, you know, I know a lot of people go online and try to find answers,
- 5:14which is totally understandable.
- 5:16And, you know, especially with AI now being a resource,
- 5:20that's quite widely available.
- 5:22But sometimes the self-diagnosis can lead us to anchor in on, you
- 5:27know, certain causes of things and can get people into trouble.
- 5:30I think that if anyone is questioning whether these symptoms may be from
- 5:34perimenopause, it could be that in the end that's what is causing it.
- 5:38But it's really important, you know, to come and see your
- 5:42provider and work through some of those questions and concerns.
- 5:46Host: Great answer for that.
- 5:48And I think you really touched on something, especially with AI.
- 5:53But also, it's just the general internet.
- 5:57It's like perimenopause content is having a moment.
- 6:02It is like the thing right now, at least.
- 6:05You know, judging from my Instagram feed, for sure.
- 6:10And I mean, on one hand, that's awesome because, you know, I think back to
- 6:16our listener talked about her mother and grandmother surviving this, and
- 6:21I'm thinking, like, my grandmother called this the change of life.
- 6:25So, you know, it's great that we actually have words to describe this.
- 6:29And we have like a language and a vocabulary to talk about it.
- 6:33But it does also seem like, you know, there is this way where it's like, you
- 6:39know, if I'm over 35 and I woke up in the morning and I can't find my keys,
- 6:45suddenly, you know, the internet is ready to tell me that my hormones have just
- 6:51given up and they've left the building.
- 6:53So, it does seem like a double-edged sword a little bit.
- 6:57Adi Rattner Nevo, MD: Absolutely.
- 6:57And, you know, social media can be a really great tool for raising awareness
- 7:02and making people feel less alone and finding community, but it does
- 7:06tend to oversimplify in particular in the area of medical education.
- 7:12Host: Yeah.
- 7:13You know, I think I've definitely seen a lot of stuff that's
- 7:18like, "This symptom means…"
- 7:20or, "Doctors won't tell you this, but…"
- 7:22you know,
- 7:25those are definitely, like, running themes that are kind of all over social
- 7:30media and the internet right now.
- 7:32Adi Rattner Nevo, MD: Absolutely.
- 7:33And I think when I talk to my patients, that's where I think
- 7:37people should be a bit skeptical or I caution people because, you know,
- 7:43rarely is there like one explanation.
- 7:46and when things tend to really simplify a concept into like
- 7:52one answer, I'm pretty wary.
- 7:56Host: I think it's a good time to help some people out, you know?
- 7:59And I think I definitely keep holding this guy up because, in researching t
- 8:05this, interview, my phone is like, "You have entered your crone years, and I'm
- 8:12only going to show you this content."
- 8:14so, let's talk about, you know, if somebody is googling symptoms
- 8:19or getting bombarded with this content, what are some good ways to
- 8:25tell that it's actually reliable?
- 8:28Adi Rattner Nevo, MD: So, some things to keep in mind,
- 8:31some of these things may help.
- 8:32First is who or what is the source?
- 8:36So, is this a licensed clinician, medical provider, or reputable
- 8:42medical organization, or sometimes, you know, academic center?
- 8:46Or is it somebody with a compelling personal story, and are they providing
- 8:52a discount code or any products that there's, like, brands that
- 8:56they're specifically promoting?
- 8:58The second thing is—and this might be a little vague at
- 9:01first—but how do they sound?
- 9:03Typically reliable sources acknowledge that there is nuance
- 9:07in many conditions or, you know, life phases like perimenopause.
- 9:12So if someone's making sweeping statements or absolute statements
- 9:16like, "This always means…"
- 9:18or, you know, "No one has ever…"
- 9:20or, you know, "Doctors are ignoring or not listening to you always,"
- 9:24you know, that's a red flag.
- 9:26You know, I do want to acknowledge that many individuals have experienced real,
- 9:30like, disenfranchisement or reasons to have mistrust in healthcare, but
- 9:34I would be cautious of just absolute statements, and black-and-white thinking.
- 9:40And the third thing is, are they trying to sell you something?
- 9:44This doesn't automatically mean that the information they're presenting
- 9:47is wrong, but there's a clear financial motivation and bias there.
- 9:53So, I would be cautious.
- 9:56And the next thing is, are they encouraging you to seek care if, you know,
- 10:03it makes sense or if things don't add up?
- 10:05So again, this is kind of feeding back into the idea of nuance.
- 10:10You know, they might present things in a certain way that's digestible.
- 10:13But ultimately, like, are they still suggesting if things don't fit this
- 10:17neat, you know, template of what they're presenting, like you should go seek
- 10:22care with your individual provider.
- 10:25Host: Yeah.
- 10:25That last point, it definitely seems especially important where it's like good
- 10:31information should lead you to a next step and not necessarily, like, replace care.
- 10:38Adi Rattner Nevo, MD: Definitely.
- 10:39And it can help you maybe recognize a pattern or like make some sense of the
- 10:45symptoms, the experiences that you're having and put the words to them,
- 10:50and help you feel seen, recognized.
- 10:54It does not take the place of, you know, having a provider talk to you and
- 10:59do a really comprehensive assessment of what is going on with your health.
- 11:04Host: I am going to keep talking about my algorithm, which is deeply
- 11:11invested iin this conversation, which, you know, it's gotten rid
- 11:16of all of my heated rivalry reels.
- 11:18Now, it's just all perimenopause all the time.
- 11:22So now, that I'm being fed all of these things, I want to benefit our
- 11:26audience and make sure that we are separating the truth from the fiction
- 11:33on the reels that are coming up, because I'm sure it's not just me.
- 11:38So, let's get to a little bit of a lightning round of questions.
- 11:44I'm going to read some statements that have come up in the course of my
- 11:50research here, and I just want you to kind of tell me if they are true, like
- 11:56generally accurate, or false, or just misleading, or just kinda incomplete.
- 12:03So, are you ready for the lightning round?
- 12:06Adi Rattner Nevo, MD: Yes.
- 12:07Host: Okay, great.
- 12:09Let's start with this one.
- 12:11If you're 35 or older and suddenly experiencing fatigue, anxiety,
- 12:16and brain fog, that's a sure sign that you are in perimenopause.
- 12:22Adi Rattner Nevo, MD: I would say false.
- 12:24Those symptoms can occur in perimenopause as we, you know, talked earlier, but they
- 12:29can also be caused by other conditions.
- 12:32And so, especially I think you said suddenly experiencing, I would definitely
- 12:39want this individual to get checked and ruled out for other conditions.
- 12:44So, that's what I would say.
- 12:45Host: Okay.
- 12:46All right.
- 12:47Question two or statement two.
- 12:51If your periods are still regular, you can't be in perimenopause.
- 12:57Adi Rattner Nevo, MD: False.
- 12:58So, changes in the cycle pattern are common in perimenopause and
- 13:02some people will experience those.
- 13:05But sometimes the other symptoms can begin before periods become
- 13:11irregular or people notice any change in their menstrual bleeding.
- 13:15So, regular periods don't completely rule out the beginning or, you
- 13:19know, the presence of perimenopause.
- 13:21Host: All right.
- 13:21This next question I am extremely, extremely invested in.
- 13:26Hair shedding in your 40s, is it often part of perimenopause?
- 13:31Adi Rattner Nevo, MD: I would say this statement maybe is incomplete.
- 13:34Hair changes can happen during perimenopause, but hair shedding
- 13:38could be caused by other conditions.
- 13:40Again, so thyroid problems, stress, iron deficiency, nutritional issues,
- 13:46some medications or other, you know, skin or scalp conditions.
- 13:51So if, you know, hair loss feels significant, or, you know, sudden
- 13:56or new, it's definitely worth coming in to talk to one of the providers
- 14:01Host: I'm going to carefully monitor that.
- 14:04Next statement.
- 14:05If your provider won't run a full hormone panel, find one that
- 14:10actually understands perimenopause.
- 14:13Adi Rattner Nevo, MD: I would say false, and I know this may feel contentious.
- 14:17But, you know, what I talk about with my patients and when we talk
- 14:22about the meaning of certain labs, hormone levels can fluctuate a
- 14:26lot during me- perimenopause.
- 14:28So, a single lab value at one point in time or on one day
- 14:33may not tell us very much.
- 14:34And in many cases, you know, it may be in the premenopausal range or, you know,
- 14:41what we'd consider normal in premenopause.
- 14:44So in many cases, our care and our decision to start different types of
- 14:49treatments is based more on the symptoms, the medical history, someone's age,
- 14:54possibly menstrual changes, you know, ruling out other medical conditions.
- 14:58And we go based more on that than necessarily the lab value.
- 15:02So, testing can be useful, in some situations, specifically,
- 15:07you know, regarding hormone level testing, but sometimes it doesn't
- 15:12necessarily add too much to the care
- 15:15I did want to address, you know, the feeling of if your provider won't run
- 15:19a full hormone panel, find someone who actually understands perimenopause.
- 15:23I will say most importantly is finding a provider with whom you feel like you can
- 15:30openly talk about your experiences and symptoms and feel validated and heard.
- 15:35You know, then talking about what, you know, what data we have and the
- 15:42research supporting, you know, different decisions and treatment approaches.
- 15:46But very important, especially as this period of time can come with changes, as
- 15:53we said, in mood and, you know, cognitive function and other things, other symptoms
- 15:59that are really meaningful to people's day-to-day experience, is finding
- 16:03someone that you feel comfortable with.
- 16:06Host: It kind of comes back to it really is kind of like peri, it's that
- 16:10kind of like shruggie pause, you know?
- 16:12It's like it's up and down all the time.
- 16:16So, that makes a lot of sense.
- 16:18Kind of related to that, and this is definitely one that this
- 16:23phone, it wants to sell me stuff.
- 16:26I'm getting two conflicting statements.
- 16:30Everyone in perimenopause needs hormone replacement therapy.
- 16:34But conversely, nobody in perimenopause needs hormone replacement therapy.
- 16:41Adi Rattner Nevo, MD: So, both are false.
- 16:43And I think, you know, we talked about absolute statements.
- 16:45And I will say hormone therapy can be very helpful for some people, and
- 16:50it's also not right for everyone.
- 16:52So, there are benefits and there are some risks.
- 16:55And so, treatment depends on the symptoms, health history, goals,
- 16:59risk factors of individuals.
- 17:01And this is where I say it's really important to feel comfortable
- 17:05with your provider navigating kind of both the benefits and the
- 17:08risks in making that decision.
- 17:10Host: That's very well said.
- 17:12And I'm happy to say I feel like we work at a place, I feel like MIT Health,
- 17:19you're going to find your person.
- 17:20I think we got a good crew.
- 17:23This one that's come up, I think this is fascinating.
- 17:26There's this very popular theory that a lot of women are getting diagnosed
- 17:34with ADHD and autism in their 30s and 40s, and they're noticing the
- 17:39symptoms because of perimenopause.
- 17:42Adi Rattner Nevo, MD: So, that statement I would say is incomplete.
- 17:45Hormonal changes, sleep disruption, stress, and the general demands of
- 17:50midlife can absolutely impact focus, mood, memory, and coping skills.
- 17:56And so for some women, it's the time where maybe long-standing ADHD becomes
- 18:02harder to compensate for or finally kind of reveals itself or is recognized.
- 18:08But it is important to remember that perimenopause
- 18:11does not cause ADHD or autism.
- 18:15So, the symptoms like brain fog, difficulty concentrating, and fatigue
- 18:19can have lots of explanations.
- 18:21That is what makes it kind of nuanced and maybe challenging to figure out.
- 18:25So, this is something that is really important to give a thorough evaluation
- 18:31and, you know, just to have caution with what little bite-sized recommendations are
- 18:39found online on reels or Instagram post.S
- 18:43Host: For sure.
- 18:44For sure.
- 18:44i have a final statement in our lightning round.
- 18:47This has been awesome.
- 18:49This one's been everywhere.
- 18:51I think the New York Times wrote about this.
- 18:53In fact, I know it did, because I read the article.
- 18:56So, it's this TikTok, Instagram thing, that a simple combination of an
- 19:03antihistamine and an acid reducer can help with lots of perimenopause symptoms.
- 19:11Adi Rattner Nevo, MD: I would say incomplete for this statement.
- 19:15You know, you can find a lot of anecdotal or like case discussion online about
- 19:20this combination of medications.
- 19:24But this is not the standard of care for most perimenopause symptoms.
- 19:28And so, I would caution people against, you know, self-treatment
- 19:34based on internet advice.
- 19:36There may be some risks.
- 19:37You know, while these medications are both available over the counter,
- 19:42they're not without long-term risks.
- 19:44If you're not sure or really seeking, you know, remedies for the symptoms
- 19:48you're experiencing, I would, again, come talk to your medical provider
- 19:55before attempting a treatment like this
- 19:58Host: .So,
- 19:58I think that that is a really great segue into kind of like talking about—because
- 20:04I think that for a lot of people it's a little hard to decide when the moment
- 20:09is that it's like, "This is my moment.
- 20:12I need to talk to a clinician.
- 20:15I need to stop talking to my best friend ChatGPT, and I need to actually talk
- 20:21to somebody at MIT Health perhaps.
- 20:24Is this something to bring up at a routine appointment?
- 20:28Should you make a specific appointment to come in to talk about this?
- 20:34It's how armed with information and symptoms should you be before
- 20:41you make that appointment and come in and talk to a clinician?
- 20:48Adi Rattner Nevo, MD: My inclination is to say, you know, if you're noticing
- 20:53a change in your body and how you're feeling, you know, in your concentration,
- 21:00noticing brain fog, anything, any of the symptoms we talked about, it's very
- 21:05reasonable to come schedule an appointment just for that, even if you're not due
- 21:10for your physical until, I don't know, six months from now or whatever it is.
- 21:15Even if the symptoms maybe still feel vague and challenging to describe,
- 21:19it's something that's worth coming in and making a plan of how this will
- 21:23be evaluated and like what are next steps, when will we check in again.
- 21:28That's what I would say.
- 21:29We're always here.
- 21:30And I sometimes have patients kind of like apologizing because they feel like
- 21:34what they came in for is not a big deal.
- 21:36But I think any change that you're noticing is worth exploring,
- 21:40even if ultimately it resolves and we say, "This wasn't it.
- 21:44This was not a different medical condition or perimenopause."
- 21:48You know, it's great to have awareness and if something changes differently in
- 21:52the future, we've already touched base.
- 21:54Host: Such a beautiful way to answer that question.
- 21:55And, you know, I think that
- 21:59it's really hard.
- 22:00I relate to a person who comes in and apologizes, because sometimes
- 22:06you feel like I need to prepare a PowerPoint presentation of evidence
- 22:10because it's like, you know, we know that it's like everyone in
- 22:14healthcare, your time is limited.
- 22:16So, it's like, "I need to make this count.
- 22:18It's important."
- 22:20So, that's really helpful to know that it's like I don't necessarily need to
- 22:25bring, you know, a mountain of evidence.
- 22:27I can just bring my concerns to an appointment.
- 22:32Adi Rattner Nevo, MD: Absolutely.
- 22:32And I think that's the beauty of primary care is that we have the
- 22:35ability to follow up with you and kind of determine what that looks like.
- 22:40you don't have to have the diagnosis all figured out before you come to see us.
- 22:44That's partly our job and, obviously we partner with you.
- 22:47But, you know, that is our entire job.
- 22:50So, it's okay if things aren't so clear yet and we'll make
- 22:54a plan to figure it out.
- 22:56Host: That's awesome.
- 22:56I mean, our MIT audience, they kind of want to have it all figured
- 23:03out before they come into any situation, which is why we love MIT.
- 23:09But we can help.
- 23:10You don't have to have everything figured out before you come in.
- 23:14Adi Rattner Nevo, MD: I think one very important thing that, you know, I'm seeing
- 23:18online is a lot of services that are, you know, providing prescription for, you
- 23:25know, menopause hormonal treatment and additionally like weight loss injections
- 23:30and for many different indications.
- 23:33And it's just kind of blowing up of compounding pharmacies online, and
- 23:39patients have access for quite a lot of money to some of these medications.
- 23:44And I would just say that, you know, we don't have enough information about how
- 23:49these pharmacies are being regulated.
- 23:51if you are considering getting those medications, I really do recommend
- 23:55that you come talk to us first, and we can hopefully help develop a
- 23:59treatment plan that feels right for you.
- 24:03Many of the providers now at MIT Health feel comfortable prescribing
- 24:07menopause hormone treatment.
- 24:09We can address the fact that our mothers and grandmothers maybe didn't
- 24:13have access to this for reasons of probably history of medical research.
- 24:19And that's a whole other, I think, podcast.
- 24:23But we do have access to high-quality data now and feel comfortable
- 24:30prescribing this as is appropriate.
- 24:32And so, we're here for you and, you know, can come up with a treatment plan
- 24:37and hopefully one that doesn't leave people spending hundreds of dollars
- 24:42online after an evaluation of several minutes by maybe not a live provider.
- 24:50Host: Thank you for pointing that out because I think that's another
- 24:53thing that it's really important to understand is, like, you know,
- 24:58we all live on the internet.
- 24:59We've all seen these ads.
- 25:00We've all seen these ads everywhere.
- 25:05And if you have had a moment where you clicked on something and went through
- 25:10an evaluation, that's not a moment to be embarrassed and not to feel comfortable
- 25:17talking to your clinician about that.
- 25:19And so, in fact, i if you have those moments where, you know, you filled
- 25:26out an online form and suddenly you're getting emails with discount codes,
- 25:29it's okay and not embarrassing to talk to your clinician about that.
- 25:36No one's going to shame you.
- 25:38You know, we all live in this world.
- 25:40We all see the same content, and it's totally okay to take a beat
- 25:48before you put in your credit card info and say, "Hang on.
- 25:53Maybe this is a moment to talk to somebody at MIT Health.
- 25:57Maybe this is a moment to talk to my clinician."
- 26:00So, thank you so much for bringing that up because it feels
- 26:05like every time you look, there's even more of it.
- 26:08So, that's definitely something that is a trend.
- 26:12Thank you so much, Adi, for being on this episode.
- 26:15I'm sure we will have you back soon.
- 26:18We have plenty of other topics.
- 26:21Maybe we can have one on the history of mental health of women's health research.
- 26:26I think that would be fun, who knows?
- 26:28But if you have a question for, office hours, please visit health.mit.edu/thrive
- 26:36to submit your question via our online form.
- 26:39And until next time, be well, and don't let your Instagram algorithm
- 26:44replace your primary care provider.