104-Human grammar democratize virtual cell laboratories

Paper Talk · Sep 29, 2025 · 18m

This paper introduces a novel computational framework that utilizes a human-interpretable grammar to encode complex multicellular systems biology models, aiming to democratize virtual cell laboratories using the open-source platform PhysiCell. This cell behavior hypothesis grammar translates plain language statements about cell interactions into mathematical models, facilitating the integration of biological knowledge and multi-omics data for in silico hypothesis testing. The authors demonstrate the framework's broad applicability by simulating complex biological processes across different…