192-Creeping Fat Fibroblasts in Crohn's Stricture Fibrosis
This article discusses research into the mechanism of intestinal fibrosis, a major complication of Crohn's disease (CD), focusing on the role of creeping fat (CF), which is mesenteric adipose tissue wrapped around the diseased bowel. The authors identified a population of pro-fibrotic, mechanosensitive CTHRC1+ fibroblasts originating from this CF, which they found are enriched at the fibrotic interface between the fat and the bowel wall in strictures. Using single-cell analysis of human tissue and a specialized mouse model, the study demonstrates that these fibroblasts promote fibrosis…
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