1178-SPAC-seq: Spatial CRISPR Screening
The researchers introduced SPAC-seq, a high-throughput technology that integrates spatial transcriptomics with CRISPR screening to map how specific gene modifications influence cellular behavior within tissue environments. To interpret this complex data, they developed TARDIS, a statistical toolkit designed to prioritize genetic targets based on their spatial phenotypes and niche preferences. Their findings revealed that losing the Icam1 gene in tumor cells creates an immunosuppressive niche that facilitates lung metastasis. Additionally, they identified the SPP1-CD44 axis as a critical…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.