1408-Glutamine Drives PARP Inhibitor Resistance
The research paper identifies a critical biological mechanism behind PARP inhibitor (PARPi) resistance in ovarian cancer, focusing on the USP14–SLC1A5 axis. The study reveals that SLC1A5, a protein responsible for glutamine transport, is frequently overexpressed in resistant cancer cells and contributes to their survival by fueling glutamine metabolism. This metabolic shift enhances DNA repair and reduces oxidative stress, allowing tumors to withstand treatment with drugs like olaparib. Scientists discovered that the enzyme USP14 directly stabilizes SLC1A5 by preventing its degradation…
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