Micro 58: Pathogenesis of Fungal Disease
This episode explores how fungi transition from environmental organisms to human pathogens. Drawing from Murray’s Chapter 58, it focuses on host–pathogen interaction and the central role of immunity.
Unlike many bacteria and viruses, fungi are often opportunistic pathogens. Disease frequently arises when host defences are impaired - whether through neutropenia, corticosteroid use, HIV infection, transplantation, or metabolic disorders such as diabetes.
The narrative centres on three core mechanisms of fungal pathogenesis:
* Adherence and colonisation of epithelial surfaces
* Tissue invasion…
The skinny
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