1209-Gate of Moment-to-Moment Memory Accessibility

Paper Talk · Jun 30, 2026 · 21m

This research identifies histaminergic neurons in the hypothalamus as the primary drivers of infraslow brain dynamics that regulate how memories are accessed from moment to moment. By monitoring mice, scientists discovered that spontaneous activity in these cells tracks an integrated brain-body state, predicting whether a subject will successfully recall a learned association. High levels of pre-cue activity act as a priming mechanism, preparing the basolateral amygdala to produce a robust neural response to environmental triggers. Conversely, suppressing these neurons through optogenetic…