1399-Broadly Neutralizing HIV Antibodies
The research details the development of an innovative animal model using rhesus macaques to overcome the long-standing challenge of inducing broadly neutralizing antibodies (bNAbs) against HIV-1. By infecting the monkeys with a specifically engineered virus called SHIV.5MUT, researchers successfully triggered a two-step immune response that rapidly produced potent antibodies targeting the V3-glycan site of the viral envelope. This process begins when initial antibodies force the virus to evolve shortened V1 loops, which inadvertently exposes critical hidden targets to the immune system. The…
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