1068-Cyto-temporal Gene Expression in Cortical Development
This research describes a new computational framework, Humous.org, designed to compare gene expression during brain development across humans, mice, and cortical organoids. By using machine vision and single-cell sequencing, the scientists discovered that while neurons are relatively similar across species, progenitor cells show significant evolutionary differences. A key finding highlights the transcription factor JUNB, which is active in human stem cells but only in mouse neurons, a shift that helps explain the larger size and slower maturation of the human cortex. The study proves that the…
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