1295-Atlas of Cerebrovascular Fibrosis in Brain Aneurysms

Paper Talk · Jul 17, 2026 · 20m

This study utilizes single-cell and spatial transcriptomics to establish a comprehensive molecular atlas of human brain aneurysms. By analyzing over 200,000 neurovascular cells, the researchers identified a critical pathological shift where structurally supportive smooth muscle cells are lost and replaced by activated perivascular fibroblasts. This fibrotic transformation is linked to an influx of specialized macrophages that trigger vascular destabilization through inflammatory signaling. The findings suggest that an intricate interplay between cerebrovascular fibrosis and myeloid…