1097-Mosaic Chromosomal Alterations in Aging Blood Genome
Researchers utilized whole-genome sequencing to investigate mosaic chromosomal alterations (mCAs) within the blood of nearly half a million participants from the UK Biobank. By developing a high-resolution computational method, the study identified over 43,000 alterations, revealing a significant increase in detection sensitivity compared to traditional techniques. This approach uncovered numerous genomic hotspots for short mutations and provided insights into the DNA-repair mechanisms that drive these changes as people age. The findings highlight how specific chromosomal deletions are linked…
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