548-CCL3-Expressing Aged Neutrophils Drive Tumor Progression
Researchers have developed a novel single-cell RNA sequencing classifier to identify tumor-associated neutrophils (TANs), which are often missed by traditional data filters due to their low mRNA content. This tool revealed that high neutrophil abundance serves as a powerful independent predictor of poor cancer prognosis across various human malignancies. The study identifies a conserved three-state differentiation trajectory in both humans and mice, progressing from "young" cells to a terminally differentiated, pro-tumor state marked by CCL3 expression. Experimental evidence demonstrates that…
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