129-Tryptophan Metabolism Restricts TLS Maturation
This article presents a study utilizing spatial transcriptomics (Stereo-seq) to investigate the heterogeneity and developmental states of tertiary lymphoid structures (TLSs) in hepatocellular carcinoma (HCC) patients. The core finding is that tumor-derived tryptophan metabolism restricts the maturation of TLSs, classifying traditionally "immature" TLSs into distinct conforming and deviating types based on their potential for immune function and maturation. The research establishes that conforming TLSs correlate with better anti-tumor immunity and improved response to immune checkpoint…
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