1212-The Cartography of KRAS Inhibitor Resistance
This paper discusses how colorectal cancer develops resistance to KRAS G12C inhibitors through complex genomic and transcriptomic shifts. Researchers found that tumors undergo epithelial cell plasticity, moving from a regenerative state to a Paneth or stem-like phenotype during treatment. This adaptation includes the emergence of pro-inflammatory pathways that persist even as the disease progresses and eventually reverts to its original fetal-like state. Spatial analysis reveals that these resistant environments are highly localized within a single tumor, involving both cancer cells and the…
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