1531-Immunological Foundations of mRNA-LNP Vaccine
This review explores the immunological mechanisms underlying the success of mRNA-lipid nanoparticle (mRNA-LNP) vaccines, which gained global prominence during the COVID-19 pandemic. The authors describe how nucleoside modifications and LNP delivery systems work together to trigger a coordinated response from both the innate and adaptive immune systems. While these vaccines are highly effective at inducing neutralizing antibodies and robust germinal center responses, the text identifies ongoing challenges such as waning immunity and vaccine reactogenicity. Current research aims to better…
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