461-SupTAC: for Spatiotemporally Protein Degradation
The paper describes the development of supramolecular targeting chimeras (SupTACs), a modular platform designed for targeted protein degradation with high spatial and temporal precision. By utilizing self-assembling nanoparticles, this technology enables the selective elimination of disease-related proteins within specific organs like the liver and lungs. The researchers demonstrated the platform's versatility across multiple species, including mice, dogs, and non-human primates, to treat conditions such as acute lung injury. Furthermore, the use of chemically caged variants allows for…
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