621-Tracking Innate Immune Activation in Multiple Sclerosis
This research article introduces 18F-flurimedrimer (18F-FMD), a novel PET imaging tracer designed to non-invasively track innate immune cell activation in the central nervous system. Using a mouse model of Multiple Sclerosis (MS), the study demonstrates that this radiolabeled dendrimer can detect neuroinflammation at both presymptomatic and acute stages of the disease. The technology provides a significant advantage over traditional MRI by specifically identifying activated myeloid cells, such as microglia and macrophages, which drive disease progression. Furthermore, the authors show that…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.