Latest / Skin Anarchy / Ivana Knezevic, Research And Development Director, NIOD

Transcript

Ivana Knezevic, Research And Development Director, NIOD · Skin Anarchy

• 0:01
  SPEAKER_00: The world looks different from behind the handlebars of a rad power bike.
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• 0:58
  SPEAKER_01: Today is an amazing and very special episode, especially it's very uh near and dear to my heart.
• 1:03
  SPEAKER_01: This brand is by far my favorite brand of all time when it comes to skincare.
• 1:09
  SPEAKER_01: I know that we've hosted them before and we have the honor and the privilege of hosting them again.
• 1:13
  SPEAKER_01: So uh without further ado, I want to introduce you guys to the research and development director for NEEO, who is Ivana Ignazovic.
• 1:23
  SPEAKER_01: So welcome to the show, Ivana.
• 1:25
  SPEAKER_01: I'm so excited you're here.
• 1:27
  SPEAKER_02: Thank you for having me.
• 1:28
  SPEAKER_01: Um, Acta, really happy to be here.
• 1:32
  SPEAKER_01: Uh so lovely hosting you, and I'd love to get started.
• 1:34
  SPEAKER_01: I want to learn all about you because I know that, you know, um being a lead for something like a line like Neod, I mean, I'm sure you've got a great journey that, you know, has led to all this.
• 1:45
  SPEAKER_01: So I'd love to learn more about your career as a great starting place.
• 1:50
  SPEAKER_01: Um thank you.
• 1:51
  SPEAKER_02: Yes, it's uh well, I I I have had a long career so far.
• 1:55
  SPEAKER_02: I over over 20 years uh experience in the industry.
• 1:59
  SPEAKER_02: And uh I started out as a pharmacist, so I have a pharmacy background.
• 2:04
  SPEAKER_02: Um, and um it's uh it it traditionally I would say it was uh really um the source of most cosmetic chemists, um, and uh it still continues to a degree today.
• 2:16
  SPEAKER_02: Uh and the great part about it is because the the education is really broad and it covers a lot of chemistry, a lot of biology, there's physiology, there's uh toxicology as well, uh, pharmacology and so forth.
• 2:30
  SPEAKER_02: So there is really a great foundation learning about um the science as well as the human body and the impact that different compounds can have on the human body.
• 2:43
  SPEAKER_02: Um and but one part of that is definitely when when you get to uh actually different uh pharmaceutical technologies and formulation, this is where some of us fall in love with formulating.
• 2:55
  SPEAKER_02: That's happened to me.
• 2:56
  SPEAKER_02: Um and uh and then after so after I graduated, uh I worked for a short time really just as a pharmacist, but I knew that was not where my heart was going to be.
• 3:05
  SPEAKER_02: And uh I was I really set on uh building this career.
• 3:09
  SPEAKER_02: So I it has gone through ups and downs, but I had really so over 20 years of bench experience developing formulations, skincare, sun care, color cosmetics, uh, some topical pharmaceuticals as well.
• 3:23
  SPEAKER_02: Um, and uh just my love and appreciation for the field really only grew, I have to say that, because there's always something to learn and it's challenging and it's ever evolving.
• 3:38
  SPEAKER_02: So, yep, that's how I come here.
• 3:40
  SPEAKER_01: Well, and the spirit of a true scientist, you know, I couldn't agree more with you.
• 3:44
  SPEAKER_01: I think that those of us who really love the science and we really love the nitty-gritty bat, you know, everything we want to know everything, right?
• 3:52
  SPEAKER_01: So I a career in just pharmacy, it couldn't have been enough, you know, uh for your mind.
• 3:57
  SPEAKER_01: So I completely understand and I'm I'm just so honored to be hosting you and to be learning from you.
• 4:02
  SPEAKER_01: I I want to actually focus today's episode for everyone listening on the brand new release by Neod, which is um, you know, one of their cult favorite products, the copper amino isolate serum.
• 4:12
  SPEAKER_01: And I know that it's been reformulated into um a beautiful uh new formula, which I love, and I want to really focus on uh case three.
• 4:20
  SPEAKER_01: So um, you know, Ivana, if you could give us a little bit of background on it.
• 4:24
  SPEAKER_01: I I had talked to um Pridvi in the first episode, and we had talked a little bit about, you know, copper isolates and and the their role in skin health, but I would love to get your your feedback and your um just I guess preliminary information you can give us about the role of copper or peptides.
• 4:42
  SPEAKER_02: Um well it's it's it's really an exciting area.
• 4:45
  SPEAKER_02: Uh I mean, you know, I'm sorry if I keep repeating exciting often, because uh it is um it is such a um such an evolving area because we are really learning about that.
• 4:57
  SPEAKER_02: So in this particular case, uh and you know, our acronyms in the lab, GHKCU, for instance, we refer to that really in that uh in that way um uh in the lab and with the formulators.
• 5:10
  SPEAKER_02: So um it is um it exists.
• 5:12
  SPEAKER_02: Um so it is a tripeptide, uh GHK, and uh it consists of um lysine hystidin and uh lysine uh amino acids.
• 5:23
  SPEAKER_02: Um so it exists in um in the human body, actually in all living organisms, and uh it is um and it complexes with copper ions.
• 5:32
  SPEAKER_02: Um so it is it it could be free sometimes, it complexes with copper ions as well because again, uh everything in the body is you know is dynamic and ever-changing and evolving and moving around.
• 5:45
  SPEAKER_02: Um so it's uh it has actually very many functions.
• 5:49
  SPEAKER_02: Um, and it was discovered in the 1970s, um, and and its importance, uh we're still learning about that, and that sort of ties in in many ways as how we see the evolution of neon as well, because as the knowledge expands, uh we we we apply that and uh we we're always on the lookout for the ladies in technologies and in the knowledge.
• 6:11
  SPEAKER_02: So copper itself, um sorry, so copper itself is uh an essential uh mineral, an essential element that is um uh really uh required for survival of um living organisms or human body.
• 6:28
  SPEAKER_02: Um and um and it works uh really in this as sort of a catalyst, but a cofactor uh like sort of has this catalyst role in different redox or um um uh metabolic uh reactions with proteins.
• 6:42
  SPEAKER_02: Now we know the proteins have uh I mean like it's not even possible to list all the roles of proteins in uh in the human body.
• 6:49
  SPEAKER_02: So, but if we group that to um obviously functional like enzymes because they're proteins, and then we have um structural uh because they really build the tissues uh as well.
• 7:02
  SPEAKER_02: So um there are multiple roles uh and multiple pathways uh that uh this little tripeptide uh complex on its own as well as complex with copper uh will participate in.
• 7:16
  SPEAKER_02: Um and uh with skin, so it is present in the human body and it's being researched extensively still and discovered, um, and uh and it can impact um that way, obviously, many different uh organs in the body, but with the skin as well.
• 7:32
  SPEAKER_02: So it is involved in um uh regeneration uh and if there is, for instance, um a damage to the skin or to the body in wound healing, um, it is uh building structural proteins like collagen, elastin, glycosaminoglycans, um, then in um fibroblasts, it will stimulate uh the growth factors.
• 7:55
  SPEAKER_02: So there are really very many um roles um that it takes part in.
• 8:02
  SPEAKER_02: It can also help with antioxidant protection from UV radiation uh to you know lipid peroxidation uh reduction, and so there are just really a vast array of activities.
• 8:15
  SPEAKER_02: So you can imagine how exciting as an ingredient it would be to cosmetic uh formulators.
• 8:23
  SPEAKER_01: Absolutely.
• 8:24
  SPEAKER_01: No, I know, and I know that you know uh I have a degree in medical physiology, a master's degree.
• 8:29
  SPEAKER_01: I was actually getting my PhD, but then I decided, you know what, I don't have another eight years because I wanted to go to med school, and I and I know that uh the role of you know, just the three amino acids that are linked together here, you know, glycine, um, histine, and lysine, those are very, very crucial in a lot of the um, you know, what do you call it, the structure of many proteins in our body that are very, very uh much at the core of, I guess, what you could say are the natural normal cellular processes that we undergo.
• 9:00
  SPEAKER_01: So I think it's very brilliant that this is the peptide that was um chosen to link copper with, because it's something that, like you said, yeah, it's naturally occurring, but it's also very much abundant in the body.
• 9:12
  SPEAKER_01: So, you know, I I think that's absolutely brilliant.
• 9:15
  SPEAKER_01: Was this something that you had to think about in terms of the design, or was it something that you just said, you know what, we already know that this is used and we're gonna go with this?
• 9:23
  SPEAKER_01: Or how I mean, I want I want to talk about the chemistry aspect of that.
• 9:26
  SPEAKER_01: Like, how did you decide on these three amino acids, or did you just go by the GHK that already exists, you know, in our body?
• 9:34
  SPEAKER_02: Um, well, our approach with uh in general, and uh with uh, I mean, there are similarities obviously the differences between different brands, but but but with NEOD, um taking a holistic approach, so understanding uh the pathways and the modes of action for finding of the active, that's really critical.
• 9:53
  SPEAKER_02: Um and uh and then obviously products are applied topically.
• 9:57
  SPEAKER_02: So for us, uh it is to to to formulate these actives to make the formula stable so that it can um you know it can actually withstand, it can be a product that can be used uh on the market and uh and then that um that it can really uh deliver what we expect from it.
• 10:15
  SPEAKER_02: Uh so it is um you know it's a combination of different stages really that the product would go through.
• 10:22
  SPEAKER_02: Um so for um for this particular ingredient, um it is um it has to be available to us.
• 10:29
  SPEAKER_02: So it's not we don't synthesize it, um, like the the the peptides.
• 10:33
  SPEAKER_02: Um we uh the the interesting thing was with uh the earlier versions of of CAIS were that um it was a do-it-yourself approach.
• 10:43
  SPEAKER_02: So you know, because you were mixing um the different things, so the the complexation with copper would take place uh in in in situ, you know, so it would take at that uh would happen at that time.
• 10:54
  SPEAKER_02: Um but uh the peptide itself, or when it was uh a copper uh salt that we received, like that we had before, these ingredients that are available to us.
• 11:04
  SPEAKER_02: So they have to come with really extensive documentation that the manufacturers would provide on um on the safety of these uh chemicals or how to formulate with them, how to use them, that then we will um use and and then try to implement within our vision, within the formula that we want to create.
• 11:25
  SPEAKER_01: Interesting.
• 11:25
  SPEAKER_01: Now I want to know um in terms of the pre-mixing, you know, because I know that before, like you said, you know, we had we were mixing it together, and then we have this beautiful blue serum that was created, and um now it's already come, like you said, it comes pre-mixed.
• 11:40
  SPEAKER_01: So now is there any kind of limitation at all with it being pre-mixed in terms of the shelf life or you know, um how active it is or anything like that?
• 11:49
  SPEAKER_01: I mean, how how has that been in terms of the chemistry and the formulation aspect?
• 11:53
  SPEAKER_02: Um well the the the reason uh for instance uh why we approached um uh the the reformulation uh were that um you know we we have uh we're we're constantly uh trying to improve uh our sustainability and uh you know, or we have different goals.
• 12:11
  SPEAKER_02: Um so this is something that we um revisited and we wanted to see whether we could meet that goal.
• 12:20
  SPEAKER_02: So we could make it more sustainable by reducing the packaging and um and still have the same, obviously the stability and the same efficacy and the formula that will deliver.
• 12:32
  SPEAKER_02: Um so that uh you know again, it is a reformulation, so we had to approach that from different angles.
• 12:39
  SPEAKER_02: Um, and uh and it took some time, but we achieved that.
• 12:43
  SPEAKER_02: So we managed uh to so that's why the product is on the market now.
• 12:47
  SPEAKER_02: We're very happy with that.
• 12:48
  SPEAKER_02: Um so to answer your questions, uh no, there are no uh really um drawbacks to now having it in one uh in one bottle.
• 12:57
  SPEAKER_02: Um it is it is safe um uh and uh it is as effective.
• 13:02
  SPEAKER_02: Um and you still you will have the like the the one-to-one, as you as I assume you will know, is represents really that there is um or represents uh one percent of uh GHK cu and one percent GHK.
• 13:16
  SPEAKER_01: Yeah, yeah, no, I know it's a one-to-one ratio.
• 13:19
  SPEAKER_01: Um now I one thing I I want to mention to all the listeners listening because I you know I think it's important to understand the science as much as we can, um, even as consumers.
• 13:27
  SPEAKER_01: And I want to mention that GHK, you know, I know Ivana had gone into uh a few of the effects or or the um roles of GHK, but GHK is actually something that is involved in the um, you know, the healing and the repair in multiple tissues in our body, not just our skin.
• 13:44
  SPEAKER_01: So that just makes it even more appealing.
• 13:46
  SPEAKER_01: You know what I mean?
• 13:47
  SPEAKER_01: Like it's like it's more, it's it's more like I guess in sync with our body than I think most peptides are.
• 13:55
  SPEAKER_01: Whereas because you know, your body will recognize it as being something that's already very predominant, it's already there, it's being it's playing a role not only in, you know, the skin, like for example, collagen elastin, uh, you know, and fibroblast, uh dermal fibroblasts, but it's also working in the lungs and it's working in, you know, um accelerating like you know, things like uh, you know, anti-cancer mechanisms and stuff.
• 14:20
  SPEAKER_01: So I think that's very important for us to understand as consumers is that the science is it's very multidimensional and it runs very deep.
• 14:26
  SPEAKER_01: So I I really, really appreciate that you guys have created something like this.
• 14:31
  SPEAKER_01: Now, one thing I want to know is that the copper that you used um in this mixture, which is pre-mixed, now was there any kind of chemical change that had to occur to the copper um that was being utilized, or was it just the same?
• 14:44
  SPEAKER_02: Um well, what we've utilized here with um uh with the with this version, with uh with the third um version of CAIS uh was uh the uh the actual complex tripeptide with copper.
• 14:58
  SPEAKER_02: Um so that is what we've used.
• 15:01
  SPEAKER_02: In the previous versions, uh we had uh the GHK tripeptide and the copper salt uh separately.
• 15:08
  SPEAKER_02: And then uh when they were mixed, there would be um uh the the complexation that the reaction would take place.
• 15:15
  SPEAKER_02: Um and that's where you saw the change in color.
• 15:19
  SPEAKER_01: Interesting.
• 15:19
  SPEAKER_01: So this one does not have the salt component then.
• 15:22
  SPEAKER_02: No.
• 15:23
  SPEAKER_01: Okay.
• 15:24
  SPEAKER_01: And what was that?
• 15:25
  SPEAKER_01: What was the role of the salts?
• 15:26
  SPEAKER_01: Like if you don't mind me asking, what was it before?
• 15:28
  SPEAKER_02: Well, it was just to carry the copper iron.
• 15:31
  SPEAKER_01: Oh, okay, okay, okay.
• 15:32
  SPEAKER_02: Yes, so it was uh it was really uh again, it was um chosen as um um you know it wouldn't it wouldn't have any if it was a safe choice, it wouldn't have any negative impact.
• 15:45
  SPEAKER_02: Um, and uh it has to have um really uh like it has to be evaluated from uh the solubility, from um the standpoint, uh whether um whether the the the well, I mean there are different ways and different salts, obviously the with the copper, but this one was that the the reaction would be favorable the way we wanted it to be.
• 16:09
  SPEAKER_02: Um so so there are all these factors that we would consider.
• 16:13
  SPEAKER_02: Um, but uh one uh one of the aspects is always that um it would be uh innocuous uh or it would even have some beneficial effects or anything like that.
• 16:24
  SPEAKER_02: That's what we would consider when we have to choose, well, any ingredient really.
• 16:28
  SPEAKER_02: So it would have been this uh the case here too.
• 16:31
  SPEAKER_01: That's very interesting.
• 16:32
  SPEAKER_01: Now, one question I do have, Ivana, is about the size of the molecule that we're working with here, because I know that you know there's a lot of conversation around um, you know, things crossing the skin barrier, and a lot of dermatologists bring this up, and it's something that I think we all want to know about.
• 16:48
  SPEAKER_01: Um, in terms of the size of this molecule in the serum, um, how big is it?
• 16:52
  SPEAKER_01: Because I know that anything under 500 Daltons is usually the ideal marker for penetration into the skin layers, right?
• 16:59
  SPEAKER_01: So, like how how was how is that in terms of the size of the um it's an excellent question.
• 17:05
  SPEAKER_02: I don't have it on the top of my head.
• 17:07
  SPEAKER_02: Um, I will look it up and let you know.
• 17:10
  SPEAKER_02: Uh you know, but Mickey, Mickey can relate that.
• 17:12
  SPEAKER_02: Um, but I believe it is it is small.
• 17:15
  SPEAKER_02: Um, and um so so yes, so the size is um one of the critical factors, uh, and then the base formula.
• 17:25
  SPEAKER_02: Um, and uh you know, so um what we find with with our studies um as as we learn you know constantly uh is that it's it's the formulas are so unique um and um how formulas behave applied topically is very much formula specific.
• 17:46
  SPEAKER_02: Um so you can uh you because in a formula, um obviously the size of the molecule, the solubility of the molecule uh are also critical factors.
• 17:56
  SPEAKER_02: Uh what else uh is in the formula?
• 17:59
  SPEAKER_02: Does that influence how the formula is deposited, um, how some of the absorption happens?
• 18:07
  SPEAKER_02: Um so all of these factors really play a role.
• 18:10
  SPEAKER_01: Yeah, and I, you know, I want to talk about like just uh like in terms of like, you know, just getting to the skin, because you know, I know a lot of people talk about that, and and and that's why I brought it up.
• 18:20
  SPEAKER_01: You know, it wasn't to like really put you on the spot, it was more that, you know, I think a lot of people think that anything that we're putting on our skin topically, it has to get through the skin layer into the dermis, it has to like be this ultra-penetrative thing, but I mean that's not always the case, right?
• 18:36
  SPEAKER_01: I mean, there's so many different effects that are happening as the you know molecules are going through the skin, you know.
• 18:43
  SPEAKER_01: The for example, you had mentioned antioxidant effects and stuff, you know, and so those things are also very um topically related because there's a lot of antioxidant potential with topical products.
• 18:54
  SPEAKER_01: And I think that you know, something like this is something that it could really be at at the cutting edge of that, is is providing that effect on just even if you put it like you know, look at it as soon as you put it on on the surface of the skin.
• 19:07
  SPEAKER_01: So I think that's very interesting.
• 19:09
  SPEAKER_02: Oh, well, all of that is interesting.
• 19:10
  SPEAKER_02: It's it's it's frankly it's fascinating because uh I guess we are learning because we have um uh we have done a clinical study um and uh we uh we are learning about uh and not less researching, but some of its uh other ongoing studies.
• 19:25
  SPEAKER_02: Um now with the application of, as you're saying, of topical application, um obviously the stratumcorneum is is a barrier and it is there for a very, very important reason.
• 19:35
  SPEAKER_02: Um and uh we we we appreciate that it has a very important role to play.
• 19:41
  SPEAKER_02: Um and uh many of the activities of different skincare products that are applied topically um really have the benefits already at the level of stratum cornea, whether on the surface or within the stratum corneum.
• 19:56
  SPEAKER_02: Um sometimes uh some of some of them will penetrate to the viable epidermis.
• 20:01
  SPEAKER_02: You know, so there are very many different um uh ways the products uh behave.
• 20:07
  SPEAKER_02: Now we are talking about cosmetic products um and uh cosmetics as uh as you know um are really not drugs.
• 20:16
  SPEAKER_02: Uh they um they have um they have a defined role um and how to be used.
• 20:23
  SPEAKER_02: So um we are uh quite, I think we're very fortunate that topically applied cosmetic products can still show um excellent benefits um on uh on the skin.
• 20:35
  SPEAKER_01: Um yeah, I mean, you know, honestly, Ivan, I want to just say, you know, one thing I've always really, really loved and appreciated about NEOD.
• 20:44
  SPEAKER_01: First of all, it's the name.
• 20:45
  SPEAKER_01: You know, it's the name is it says it all, you know, it's non-invasive options in dermal science.
• 20:51
  SPEAKER_01: I mean, that is something that I I think I went on a rant earlier in like you know, uh last month or something about I did a mini episode about talking about how you know we were taught in medical school non-invasive, non-invasive, non-invasive.
• 21:04
  SPEAKER_01: You know what I mean?
• 21:05
  SPEAKER_01: You don't want to tell your patients, hey, let me inject a needle into you first and foremost.
• 21:10
  SPEAKER_01: That's the last thing you want to do.
• 21:11
  SPEAKER_01: You know, you want to go with the non-invasive options.
• 21:14
  SPEAKER_01: So the fact that, you know, your whole uh the whole company, the whole line is based on this idea of non-invasive options is just so magnificent to me.
• 21:23
  SPEAKER_01: And I absolutely uh really love that.
• 21:25
  SPEAKER_01: So I just wanted to, you know, I want to say that to everyone listening is that, you know, this is this is a line that is so true to science and it's so true to like chemistry and biology and physiology, like Ivana mentioned, that you know, it's definitely something that you need to at least, at the very least, try because we can't always be going to an injector and getting Botox and stuff for things that you know could very well be working if we do topical applications, you know.
• 21:50
  SPEAKER_01: So that's actually it it leads me into another question for you is that, you know, what is the layering that you suggest for users?
• 21:58
  SPEAKER_01: Now I know that Neod um products.
• 22:00
  SPEAKER_01: Are very um very good about kind of on the packaging.
• 22:03
  SPEAKER_01: It mentions like you know, you want to apply this first and then this.
• 22:06
  SPEAKER_01: So, can you give us kind of like a rundown of maybe two or three products in the line that we would use with this product and how it would be layered?
• 22:15
  SPEAKER_02: Uh well, there I mean there are different options because again every every skin is unique, um, and uh you know, and regimen depending at what uh what stage of in life um or the condition of the skin.
• 22:28
  SPEAKER_02: So all of that is really considered by every by every consumer, by every skin user.
• 22:33
  SPEAKER_02: We all are, you know, we we all use skincare and you know we we all uh are in the in that position.
• 22:39
  SPEAKER_02: Um so what what we uh uh when we recommend uh how to layer products, we we look at a number of things.
• 22:46
  SPEAKER_02: Uh we look at a texture and solubility of products um and uh their the viscosity, how they spread, um, as well as are there any uh factors in terms of that we know, for instance, um how the efficacy of the product will be impacted.
• 23:03
  SPEAKER_02: You know, so there are a number of things that we consider when uh when we're making a recommendation.
• 23:08
  SPEAKER_02: So what we would uh do is uh you know, we will have uh, for instance, um something along the lines of cleansing.
• 23:16
  SPEAKER_02: It is one of the critical steps.
• 23:19
  SPEAKER_02: Um and uh you know with uh with neon, we have um LVCE and uh which is uh which is really uh a very light ester um and emollient.
• 23:31
  SPEAKER_02: It is easy uh to uh you know to use uh to utilize.
• 23:34
  SPEAKER_02: It can remove makeup.
• 23:36
  SPEAKER_02: We have Sanskrit saponins as well, um, and they can be combined or just one can be used depending on on a skin type.
• 23:43
  SPEAKER_02: Um and then it depends on the complexity of um you know for for the user.
• 23:49
  SPEAKER_02: So we would have um, for instance, um I will use uh CAIS uh both morning and uh evening um right after uh right after I would do the cleansing.
• 24:03
  SPEAKER_02: Um and then um and then I will um you know follow up with uh uh MMHC.
• 24:10
  SPEAKER_02: Um or uh you know sometimes I will uh you know drop something from the ordinary uh line and uh and then apply that like the NMF and HA.
• 24:20
  SPEAKER_02: So I would I would combine things um you know in different um in different ways uh as everyone else does um I would um I would expect.
• 24:32
  SPEAKER_02: But uh one of the neot uh regimens that uh that we have really um researched uh lately and been recommending to a lot of um our um our customers is to start with cleansing again, L V C E or uh you know Sanskrit sapponins if that is the preference, then to um to apply uh then to uh use the uh C AIS than to uh apply um um um the fractionated eye con you know concentrate because around the eye area.
• 25:13
  SPEAKER_02: Um during the day, uh MMHC and then sunscreen is really uh critical.
• 25:21
  SPEAKER_02: So uh survival survival 30 is uh what uh what I would recommend, what we generally recommend depending on the the season, the time of year, the skin type.
• 25:32
  SPEAKER_02: Um and then um in the evening um it would be um again, this is very simple.
• 25:39
  SPEAKER_02: Um cleansing, um, C AIS, uh, then uh the uh the AFACC around the eyes uh and then MMHC.
• 25:49
  SPEAKER_01: Or you could be like me and be obsessed with their voicemail mask and just use that in the evenings because I love that.
• 25:55
  SPEAKER_01: I love that mask so much.
• 25:57
  SPEAKER_01: It's like my favorite, it's one of my favorite products.
• 25:59
  SPEAKER_01: But I love that.
• 26:00
  SPEAKER_01: Thank you so much for uh going through that because I know that consumers are always looking for some insight, you know, in terms of layering and what to use first.
• 26:07
  SPEAKER_01: And you know, just I love the consistency of the serum too.
• 26:10
  SPEAKER_01: It's so it's so water-based, you know, in terms of like it's very, very light, and so it just seeps right into the skin.
• 26:15
  SPEAKER_01: It just it's beautiful.
• 26:17
  SPEAKER_01: I love it.
• 26:18
  SPEAKER_01: So um, you know, I love it too.
• 26:20
  SPEAKER_02: Again, I I have to add that.
• 26:21
  SPEAKER_02: And I love masks too.
• 26:23
  SPEAKER_02: Uh, I I try to really use them uh about three times, sometimes four times a week, and I and I like to alternate.
• 26:30
  SPEAKER_02: But with my with my regimen, I I like to stay with the same um program for a while because uh in order to really get the results, uh, you do need to be consistent with using your regimen uh to give the the products a fair chance to really show the results.
• 26:49
  SPEAKER_02: Um so I would I would say uh generally uh minimum uh two months but three months would be ideal if if you are a person who likes to change around and uh and you know just uh do uh just display with different products.
• 27:05
  SPEAKER_01: Absolutely.
• 27:06
  SPEAKER_01: I love that you mentioned that because you really did answer my next question was about the the timeline of how long we should stick with products, but I I love that and I I completely agree.
• 27:15
  SPEAKER_01: I think that um any of Niod's products are just you know they're hallmark products, they really are.
• 27:21
  SPEAKER_01: And I say that with you know the most genuine like you know, sentiment that I can for everyone listening.
• 27:28
  SPEAKER_01: I mean, this line is just it's phenomenal.
• 27:31
  SPEAKER_01: It's phenomenal.
• 27:31
  SPEAKER_01: I mean, the science and you know, I really commend you, Ivana, your whole team, you know, like I think I told uh Pridvi this as well when I interviewed him.
• 27:39
  SPEAKER_01: I'm just you guys are so impressive, and you're just true scientists, and everything that you're creating is just magnificent.
• 27:47
  SPEAKER_01: And I think it deserves all the recognition in the world, and your hard work deserves all the recognition in the world.
• 27:52
  SPEAKER_01: So thank you for bringing us no really I mean it.
• 27:56
  SPEAKER_01: I really mean it.
• 27:58
  SPEAKER_02: It's really lovely.
• 27:59
  SPEAKER_02: Well, and I'm sorry to cut in, but you as you know, the uh or I'm sure you do, the the evolution of uh and how Neo started and and then Pruvi has been you know uh with from the start and uh he continues to lead our innovation.
• 28:16
  SPEAKER_02: Um and uh it's we we are all passionate.
• 28:20
  SPEAKER_02: We we we love science, we we know that it can make a difference um and uh and approaching and having this approach to not really follow any specific trend or or anything that is particularly popular at the time, or uh, you know, it really is about uh science and and viewing um every aspect of if we are considering a skin condition or a skin concern.
• 28:47
  SPEAKER_02: Uh you know, that it just sort of let's learn about it as much as we can, uh, so that it's a holistic approach.
• 28:53
  SPEAKER_02: Um and uh and then of course science is very humbling because uh, as much as we know and as much as we learn, there's still a lot to learn and and a lot to discover.
• 29:04
  SPEAKER_02: Um, so it's an ever-evolving process uh for for anyone working uh in the scientific uh area, and it applies here as well.
• 29:14
  SPEAKER_02: And and I personally find that that's really beautifully reflected in NEOD, um, because NEOD is evolving too, um, with um sometimes the same product, and we see that with with uh CAIS, we we see that with other products as well.
• 29:29
  SPEAKER_02: So it's it's always just always on the lookout um to see to find the best, and and then how to bring that together for for a really um beautiful product.
• 29:42
  SPEAKER_01: You know, Ivana, I think I told Perthy this, but I also want to share this with you.
• 29:46
  SPEAKER_01: I think when I fell in love with the line, it was when I saw the um superoxide dismutase mist.
• 29:52
  SPEAKER_01: And you know, when I saw that, I was like, they put the name of the enzyme on the bottle.
• 29:58
  SPEAKER_01: I don't know how much more science forward you can get in skincare.
• 30:02
  SPEAKER_01: It was just like the most for me, like the biggest geek out moment, the biggest nerd moment.
• 30:07
  SPEAKER_01: I just fell in love with the line and I just, you know, I can't rave enough about it.
• 30:11
  SPEAKER_01: And I and I do want to thank you so much for coming onto the show and and really telling us about this new launch.
• 30:16
  SPEAKER_01: It's been, you know, lovely using it.
• 30:18
  SPEAKER_01: I've been using it um constantly since I got it, and I have it's absolutely a staple in my skincare routine.
• 30:24
  SPEAKER_01: And I urge everyone out there if peptides are something you're curious about, if it's something that you really want to incorporate into your routine and you want to um, you know, just you don't know where to start, this is the right place to start.
• 30:37
  SPEAKER_01: Always, always go for um options that are backed with science and NEOD is truly, you know, it's the crown jewel, I say, of the skincare industry, you know, because it's it's a beautiful line and it's really, really formulated by a team that knows what they're doing.
• 30:53
  SPEAKER_01: And and one thing I really love about your team is how diverse you guys are.
• 30:57
  SPEAKER_01: You know, when I first met Pridzvi and now you, and I just I realized, you know, the science, it science knows no boundaries, it knows no, you know, geographical, you know, limitations that you guys are, you know, it represents like the the diversity of your team represents the true science and the true innovation um leading, you know, uh idea of your line.
• 31:18
  SPEAKER_01: So yeah, thank you so much, Yvana.
• 31:20
  SPEAKER_01: This has been lovely, and um, I will be you know pushing this everywhere I can on my social media channels because I'm a huge fan.
• 31:28
  SPEAKER_02: Thank you so much.
• 31:29
  SPEAKER_02: This is absolutely a lovely experience today, and I appreciate uh you um having me on and um thank you again for for for the love and enthusiasm.
• 31:41
  SPEAKER_02: Um it's just reflecting uh how we feel about our work.
• 31:45
  SPEAKER_01: Absolutely, and a huge shout out to Mikey because I love you and you are always so kind to me.
• 31:51
  SPEAKER_01: So thank you so much, and thank you everyone for listening.
• 31:54
  SPEAKER_01: Um, thank you everyone for tuning in.
• 31:56
  SPEAKER_01: And I really, really hope that you um check out all the links that I post with this episode.
• 32:01
  SPEAKER_01: We're also going to be sending out a newsletter all about the uh the brand new product that we talked about here, and I want you guys to really genuinely go check it out.
• 32:10
  SPEAKER_01: If there's one skincare product you buy this holiday season, it's this one.
• 32:15
  SPEAKER_01: So check it out, and I'll be back next time, guys.
• 32:17
  SPEAKER_01: Thank you so much.
• 32:19
  SPEAKER_01: Hey guys, so I hope you love that episode.
• 32:22
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• 32:27
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• 32:44
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• 33:05
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• 33:10
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• 33:21
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• 33:26
  SPEAKER_01: Thank you.