How Telomere Dysfunction Affects Female Fertility (A Mouse Study)
Telomeres are the protective caps at the ends of chromosomes that prevent DNA damage and maintain genomic stability. However, telomeres shorten with each cell division and eventually reach a critical length that triggers cellular senescence or death. Telomere length (TL) and telomerase activity (TA), the enzyme that replenishes telomeric repeats, are influenced by genetic and environmental factors and vary among tissues and individuals. “Telomere attrition has been identified as one of the molecular determinants of aging [7].” Telomere dysfunction has been implicated in various age-related…
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