1281-hiPS Cell Model for Holistic Study of EMT Transitions
This research introduces a robust experimental framework using human induced pluripotent stem (hiPS) cells to standardize the study of the epithelial-to-mesenchymal transition (EMT). By utilizing both two-dimensional colonies and three-dimensional lumenoids, the authors provide a multimodal platform to observe functional, molecular, and organizational changes in a controlled environment. The study demonstrates that cell culture geometry significantly influences the timing of migration, with 3D structures exhibiting a delay compared to 2D formats. This delay is attributed to the presence of a…
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