050-Insulin resistance in early-onset colorectal cancer
This paper explores the increasing incidence of early-onset colorectal cancer (EOCRC), highlighting its distinct characteristics compared to late-onset cases. It proposes that insulin resistance (InsR), often linked to lifestyle factors and metabolic imbalances, acts as a primary trigger for EOCRC development in younger individuals. The discussion details how InsR contributes to carcinogenesis through mechanisms like hyperinsulinemia, chronic inflammation, microbiome dysbiosis, and accelerated cellular aging. Finally, the text advocates for earlier detection strategies, lifestyle…
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