882-Map of Human Hematopoietic Stem Cell Differentiation
This study provides a comprehensive molecular map of human hematopoietic stem cell (HSC) differentiation across various stages of life. By utilizing advanced single-cell proteo-transcriptomic sequencing, researchers identified four distinct trajectories for cell development that remain largely consistent as humans age. A key finding is the identification of CD273 (PD-L2) as a surface marker for a specific group of quiescent, immature stem cells. Beyond serving as a marker for dormancy, this protein allows stem cells to perform an immune-modulatory role by suppressing T-cell activation. While…
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