533-SLC45A1 Loss and the Neural Lysosomal Proteome Landscape

Paper Talk · Feb 21, 2026 · 18m

Researchers developed a cell-type-specific lysosomal atlas of the brain using LysoIP and proteomics. They identified SLC45A1 as a critical lysosomal glucose transporter in neurons. Its absence impairs lysosomal acidity, V-ATPase assembly, and metabolic recycling, linked to disease.

References:

Ghoochani A, Heiby J C, Rawat E S, et al. Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder[J]. Cell, 2026.

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