569-SpaceTracer: High-Resolution Spatial Lineage Tracing
The paper introduces SpaceTracer, a new computational framework designed to identify somatic mutations directly from spatial transcriptomics data. By detecting these genetic alterations, the tool allows researchers to perform lineage tracing within the natural architecture of human tissues, bypasssing the need for invasive genetic manipulations. The authors demonstrate that this method can effectively reconstruct the evolutionary history of tumors, revealing how specific cell populations migrate and interact within their environment. Application of the tool to cutaneous squamous cell…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.