301-apCAF Spatial Niches Define SPP1-Driven Tumor Virulence
This article utilizes single-cell resolution spatial analysis across multiple solid tumors to characterize antigen-presenting cancer-associated fibroblasts (apCAFs). The study reveals two distinct apCAF populations—M-apCAFs (mesothelial-related) and F-apCAFs (fibrocyte-related)—that exhibit different spatial localizations within the tumor microenvironment. Specifically, the F-apCAFs are found predominantly in lymphocyte-enriched niches, while the M-apCAFs associate closely with cancer cells. A major functional finding is that both apCAF populations are the primary stromal source for secreted…
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