1379-Vitamin C Decelerates Primate Bone Marrow Aging
This research analyzes how long-term vitamin C supplementation can slow the biological aging of primate bone marrow. By utilizing single-cell transcriptomic mapping of cynomolgus monkeys, scientists discovered that aging causes a depletion of immune-related progenitor cells and a shift toward inflammation. Vitamin C administration partially reversed these effects, restoring lymphoid cell populations and reducing the molecular age of the tissue by approximately four years. The study identifies progranulin as a key protein that mediates these protective benefits against age-related decline…
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