1173-Pathogenesis Profiling of DLBCL Proteogenotypes

Paper Talk · Jun 23, 2026 · 22m

This research identifies seven molecularly distinct proteogenotypes (PGs) of diffuse large B cell lymphoma (DLBCL) by integrating proteomic, transcriptomic, and genomic data. While traditional subtyping focuses on genetic mutations or cell-of-origin, this integrated multi-omic approach reveals shared oncogenic pathways and microenvironment features that explain clinical heterogeneity more accurately. A primary finding is the identification of PG4, a high-risk group associated with poor R-CHOP therapy outcomes and a unique biological signature of enhanced MYC activity and T cell exhaustion…