652-Postsynaptic AMPAR Regulate Short-Term Plasticity

Paper Talk · Mar 17, 2026 · 19m

This research identifies AMPAR surface diffusion and desensitization as critical postsynaptic mechanisms that work alongside presynaptic release to regulate short-term plasticity (STP). By utilizing advanced molecular tools and imaging in intact brain circuits, the authors demonstrate that receptor mobility counteracts synaptic depression by replacing desensitized receptors with functional ones during repetitive activity. These postsynaptic dynamics are synapse-specific, appearing more influential in the somatosensory cortex than in the hippocampus due to differing receptor compositions…