1615-Multi-Omic Profiling of Hepatocellular Carcinoma

Paper Talk · Sep 25, 2026 · 21m

The paper outlines a comprehensive genomic and transcriptomic study of hepatocellular carcinoma (HCC) aimed at refining the disease's molecular classification. By integrating multi-omics data from 529 French patients and validating findings in an external cohort of over 800 cases, researchers identified nine distinct molecular subtypes driven by specific mutations and immune profiles. Key findings include the discovery of a rare, aggressive TP53+CTNNB1ex3 subtype, where TP53 mutations typically precede β-catenin activation, leading to poor clinical outcomes. The study also characterizes rare…