A Randomized Trial of Nefopam for Postoperative Pain Management in Obstructive Sleep Apnea Patients Undergoing Uvulopalatopharyngoplasty
The take-home point. Nefopam did not lower morphine after UPPP. On the first day, patients used a median of seven milligrams with nefopam and five with placebo, both remarkably little. On top of a strong scheduled regimen, the extra drug bought nothing this trial could detect. The decision this paper informs is whether to add nefopam to a pain regimen after palate surgery. It supports the authors' advice against routine add-on use, without proving the drug ineffective. For American surgeons, where nefopam isn't approved, the lesson is about adjuncts in general. An adjunct needs room to work…
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