833-Blood Extracellular MicroRNAs Modulate Social Behavior
The research explores how extracellular vesicles (EVs) and their microRNA cargo serve as a critical communication bridge between the immune system and the brain to regulate social behavior. Scientists discovered that transferring blood-borne EVs from healthy mice into models with social deficits, such as immunodeficient Rag1-/- mice, successfully restored normal sociability levels. These EVs travel through the bloodstream, enter the brain, and target neurons in the prefrontal cortex, where they deliver specific miRNAs like miR-23a-3p. This molecular delivery system improves inhibitory…
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