Nedarim 80: Defining Affliction
A study of self-affliction: what is "inui"? What needs to be prohibited from oneself? With bathing as the example. Also, the question of how not bathing is suffering (or not, as the case may be) in the context of Yom Kippur, and where the karet punishment might kick in. Note that discomfort and affliction may not quite define halakhic "inui."
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