676-Single-Cell Profiling of Multiple Myeloma Tumor Cells

Paper Talk · Mar 22, 2026 · 21m

This research introduces SWIFT-seq, a novel single-cell sequencing workflow designed to monitor multiple myeloma through a simple blood draw. By analyzing circulating tumor cells (CTCs), the method provides a noninvasive alternative to painful bone marrow biopsies, which are often difficult to perform frequently. The study demonstrates that SWIFT-seq accurately identifies cytogenetic abnormalities and measures tumor proliferation using as few as ten cells. It further establishes a circulatory capacity signature that explains how specific genetic traits drive cancer cells into the bloodstream…