1113-Monoclonal Antibodies Targeting Measles Proteins
This research identifies a new panel of human monoclonal antibodies isolated from an individual years after receiving the Measles-Mumps-Rubella (MMR) vaccine. These antibodies target the two primary surface glycoproteins of the measles virus, known as hemagglutinin (H) and fusion (F), which are essential for viral entry into host cells. Scientists mapped these antibodies into nine distinct epitope clusters and discovered several candidates with picomolar-level neutralization potency against diverse viral strains. High-resolution cryo-electron microscopy revealed that the most effective…
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