228-ERG-Driven Prostate Cancer Requires KMT2A and DOT1L
The article details research into the initiation mechanism of ERG-driven prostate cancer (PCa), a highly prevalent form in Western populations. Using a combination of lineage tracing and single-cell analysis in mouse models and human samples, the study identifies that PCa initiates in a rare subset of basal cells called BasalLum cells, which coexpress luminal genes. These BasalLum cells quickly transition into a highly proliferative, multi-lineage intermediate (IM) cell population that ultimately differentiates into invasive luminal adenocarcinomas. Mechanistically, the authors discover that…
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