087-Cellular biogeography of human bone marrow
This comprehensive resource paper presents a multi-omic atlas of human bone marrow, combining single-cell RNA sequencing (scRNA-seq) and co-detection by indexing (CODEX) imaging to map cellular composition, spatial architecture, and cell-cell communication. The study reveals heterogeneity within mesenchymal stromal cells (MSCs), identifying distinct subsets like Adipo- and THY1+ MSCs as primary producers of hematopoietic support factors such as CXCL12, KITLG, CSF1, and IL-7. It further characterizes the spatial organization of hematopoietic stem and progenitor cells (HSPCs), showing a…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.