665-CRTAM as a T Cell Checkpoint for Immunotherapy Toxicity

Paper Talk · Mar 19, 2026 · 16m

This research identifies CRTAM as a critical immune-related adverse event (irAE) checkpoint that governs the balance between immunotherapy efficacy and side effects. By analyzing patient data and mouse models, the authors discovered that CRTAM+ T cells drive inflammatory toxicity in normal organs like the lungs and colon without significantly affecting antitumor immunity. This specific toxicity occurs because CRTAM interacts with CADM1, a protein found more abundantly in healthy epithelial tissues than in malignant tumors. Experiments showed that inhibiting or deleting CRTAM reduces severe…