1109-IFN-I & TREM2 Dysregulation in Neurodevelopment
This research explores how maternal immune activation (MIA), triggered by viral-like infections during pregnancy, disrupts the brain development of offspring and increases the risk of neurodevelopmental disorders. By utilizing mouse models, researchers identified that an elevation in maternal type I interferon (IFN-I) leads to the dysregulation of TREM2, a vital protein that governs how immune cells prune synapses. This process causes significant synaptic dysfunction and altered neuronal activity in the developing hippocampus, mirroring genetic signatures found in postmortem tissues of…
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