1663-Single-Cell Atlas Across Brain Disorders
The paper describes the PsychAD cohort, a massive single-nucleus transcriptomic study of the human dorsolateral prefrontal cortex involving over 6.3 million nuclei from 1,494 donors. This research creates a comprehensive cellular atlas to identify how gene expression changes across eight different neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s and schizophrenia. By establishing a unified cellular taxonomy, the study reveals universal molecular signatures shared across diseases, such as disruptions in protein localization and mRNA processing. It further distinguishes…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.